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Depletion and Supplementation of Coenzyme Q10 in Secondary Deficiency Disorders

Mantle, D, Turton, N and Hargreaves, IP (2022) Depletion and Supplementation of Coenzyme Q10 in Secondary Deficiency Disorders. Frontiers in Bioscience-Landmark, 27 (12). p. 322. ISSN 2768-6701

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Coenzyme Q10 (CoQ10) deficiency is broadly divided into two types, primary and secondary. Primary CoQ10 deficiencies are relatively rare disorders resulting from mutations in genes directly involved in the CoQ10 biosynthetic pathway, and are not a subject of this article. Secondary CoQ10 disorders are relatively common, and may occur for a variety of reasons; these include mutations in genes not directly related to the synthetic pathway, oxidative stress induced reduction of CoQ10, and the effects of pharmacological agents such as statins. CoQ10 is of key importance in cell metabolism; in addition to its role in mitochondrial oxidative phosphorylation, it is a major endogenous antioxidant, and has a role in the metabolism of sulphides, lipids and amino acids. Given its importance in cell metabolism, it is unsurprising that secondary CoQ10 deficiency has been linked with a wide range of disorders. In this article, we have reviewed evidence of secondary CoQ10 deficiency in both common and less common disorders, and highlighted those disorders in which CoQ10 supplementation has been shown to be of significant clinical benefit.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: IMR Press
SWORD Depositor: A Symplectic
Date Deposited: 23 Dec 2022 17:09
Last Modified: 23 Dec 2022 17:15
DOI or ID number: 10.31083/j.fbl2712322
URI: https://researchonline.ljmu.ac.uk/id/eprint/18512
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