Gomes, B, Hedman, K, Kuznetsova, T, Cauwenberghs, N, Hsu, D, Kobayashi, Y, Ingelsson, E, Oxborough, D, George, K, Salerno, M, Ashley, E and Haddad, F (2023) Defining left ventricular remodeling using lean body mass allometry: a UK Biobank study. European Journal of Applied Physiology. ISSN 1439-6327

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Abstract

Purpose: The geometric patterns of ventricular remodeling are determined using indexed left ventricular mass (LVM), end-diastolic volume (LVEDV) and concentricity, most often measured using the mass-to-volume ratio (MVR). The aims of this study were to validate lean body mass (LBM)-based allometric coefficients for scaling and to determine an index of concentricity that is independent of both volume and LBM.
Methods: Participants from the UK Biobank who underwent both CMR and dual-energy X-ray absorptiometry (DXA) during 2014-2015 were considered (n = 5064). We excluded participants aged ≥ 70 years or those with cardiometabolic risk factors. We determined allometric coefficients for scaling using linear regression of the logarithmically transformed ventricular remodeling parameters. We further defined a multiplicative allometric relationship for LV concentricity (LVC) adjusting for both LVEDV and LBM.
Results: A total of 1638 individuals (1057 female) were included. In subjects with lower body fat percentage (< 25% in males, < 35% in females, n = 644), the LBM allometric coefficients for scaling LVM and LVEDV were 0.85 ± 0.06 and 0.85 ± 0.03 respectively (R2 = 0.61 and 0.57, P < 0.001), with no evidence of sex-allometry interaction. While the MVR was independent of LBM, it demonstrated a negative association with LVEDV in (females: r = - 0.44, P < 0.001; males: - 0.38, P < 0.001). In contrast, LVC was independent of both LVEDV and LBM [LVC = LVM/(LVEDV0.40 × LBM0.50)] leading to increased overlap between LV hypertrophy and higher concentricity.
Conclusions: We validated allometric coefficients for LBM-based scaling for CMR indexed parameters relevant for classifying geometric patterns of ventricular remodeling.

Item Type:	Article
Additional Information:	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00421-022-05125-9
Uncontrolled Keywords:	Adiposity; Allometry; Body composition; LV hypertrophy; Obesity; Scaling; Ventricular remodeling; Visceral fat; 1106 Human Movement and Sports Sciences; Sport Sciences
Subjects:	Q Science > QP Physiology R Medicine > RC Internal medicine > RC1200 Sports Medicine G Geography. Anthropology. Recreation > GV Recreation Leisure > GV561 Sports
Divisions:	Sport & Exercise Sciences
Publisher:	Springer Verlag
SWORD Depositor:	A Symplectic
Date Deposited:	27 Feb 2023 10:13
Last Modified:	08 Jan 2024 00:50
DOI or ID number:	10.1007/s00421-022-05125-9
URI:	https://researchonline.ljmu.ac.uk/id/eprint/18609

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