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Applications of Electron Paramagnetic Resonance Spectroscopy in Natural Product Research

Fielding, A (2022) Applications of Electron Paramagnetic Resonance Spectroscopy in Natural Product Research. Journal of Natural Products Discovery, 1 (3). ISSN 2755-1997

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Open Access URL: https://doi.org/10.24377/jnpd.article725 (Published version)


Background: Applications of electron paramagnetic resonance (EPR) spectroscopy to natural product research have proven useful to understand the properties of natural product extracts and their intrinsic compounds. There are few reviews on this subject written as an initial introduction.
Aims: To provide an explanatory review of EPR spectroscopy applied to natural products research.
Methods: The search for this review was carried out in the following databases: SciFinder, Google Scholar, PubMed, MEDLINE, and Science Direct, with particular emphasis on publications from the last decade.
Results: The articles chosen typically used EPR to provide qualitative and quantitative data of radicals or the action of radicals in natural product research. Studies include the measurement of radical scavenging capacity, singlet oxygen detection and direct detection of semiquinone radicals in extracts. Other applications include the study of autooxidation, and photochemical properties.
Conclusion: The current trend for use of EPR in natural products research is by far in radical scavenging capacity. A fast array of experimental methods and reaction chemistry are available to tailor for biological context, which is a great advantage of the versatility of EPR. Previous ground-breaking use in detection of semiquinone radicals in extracts has waned, however, given the prevalence for quinones in plants, and cheaper bench top EPR instruments, there must be an opportunity for this to progress further. The current generation of EPR instruments offers new opportunities to probe natural product molecules and extracts with greater resolution.

Item Type: Article
Uncontrolled Keywords: EPR, natural products, extracts, quinones
Subjects: Q Science > Q Science (General)
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: LJMU
SWORD Depositor: A Symplectic
Date Deposited: 14 Feb 2023 11:09
Last Modified: 14 Feb 2023 11:15
DOI or ID number: 10.24377/jnpd.article725
URI: https://researchonline.ljmu.ac.uk/id/eprint/18888
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