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Timed exercise stabilizes behavioral rhythms but not molecular programs in the brain's suprachiasmatic clock

Hitrec, T, Petit, C, Cryer, E, Muir, C, Tal, N, Fustin, JM, Hughes, ATL and Piggins, HD (2023) Timed exercise stabilizes behavioral rhythms but not molecular programs in the brain's suprachiasmatic clock. iScience, 26 (2). ISSN 2589-0042

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Open Access URL: https://doi.org/10.1016/j.isci.2023.106002 (Published version)


Timed daily access to a running-wheel (scheduled voluntary exercise; SVE) synchronizes rodent circadian rhythms and promotes stable, 24h rhythms in animals with genetically targeted impairment of neuropeptide signaling (Vipr2−/− mice). Here we used RNA-seq and/or qRT-PCR to assess how this neuropeptide signaling impairment as well as SVE shapes molecular programs in the brain clock (suprachiasmatic nuclei; SCN) and peripheral tissues (liver and lung). Compared to Vipr2+/+ animals, the SCN transcriptome of Vipr2−/− mice showed extensive dysregulation which included core clock components, transcription factors, and neurochemicals. Furthermore, although SVE stabilized behavioral rhythms in these animals, the SCN transcriptome remained dysregulated. The molecular programs in the lung and liver of Vipr2−/− mice were partially intact, although their response to SVE differed to that of these peripheral tissues in the Vipr2+/+ mice. These findings highlight that SVE can correct behavioral abnormalities in circadian rhythms without causing large scale alterations to the SCN transcriptome.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Biological & Environmental Sciences (from Sep 19)
Publisher: Elsevier BV
SWORD Depositor: A Symplectic
Date Deposited: 15 Feb 2023 12:23
Last Modified: 15 Feb 2023 12:23
DOI or ID number: 10.1016/j.isci.2023.106002
URI: https://researchonline.ljmu.ac.uk/id/eprint/18900
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