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Trouwborst, I, Gijbels, A, Jardon, KM, Siebelink, E, Hul, GB, Wanders, L, Erdos, B, Péter, S, Singh-Povel, CM, de Vogel-van den Bosch, J, Adriaens, ME, Arts, ICW, Thijssen, DHJ, Feskens, EJM, Goossens, GH, Afman, LA and Blaak, EE (2023) Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial. Cell Metabolism, 35 (1). pp. 71-83. ISSN 1550-4131
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Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype.pdf - Published Version Available under License Creative Commons Attribution. Download (2MB) | Preview |
Abstract
Precision nutrition based on metabolic phenotype may increase the effectiveness of interventions. In this proof-of-concept study, we investigated the effect of modulating dietary macronutrient composition according to muscle insulin-resistant (MIR) or liver insulin-resistant (LIR) phenotypes on cardiometabolic health. Women and men with MIR or LIR (n = 242, body mass index [BMI] 25–40 kg/m2, 40–75 years) were randomized to phenotype diet (PhenoDiet) group A or B and followed a 12-week high-monounsaturated fatty acid (HMUFA) diet or low-fat, high-protein, and high-fiber diet (LFHP) (PhenoDiet group A, MIR/HMUFA and LIR/LFHP; PhenoDiet group B, MIR/LFHP and LIR/HMUFA). PhenoDiet group B showed no significant improvements in the primary outcome disposition index, but greater improvements in insulin sensitivity, glucose homeostasis, serum triacylglycerol, and C-reactive protein compared with PhenoDiet group A were observed. We demonstrate that modulating macronutrient composition within the dietary guidelines based on tissue-specific insulin resistance (IR) phenotype enhances cardiometabolic health improvements.
| Item Type: | Article |
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| Uncontrolled Keywords: | Humans; Cardiovascular Diseases; Insulin Resistance; Insulin; Diet, Fat-Restricted; Phenotype; Adult; Aged; Middle Aged; Female; cardiometabolic health; dietary intervention trial; glucose homeostasis; metabotyping; precision nutrition; tissue-specific insulin resistance; Female; Humans; Cardiovascular Diseases; Diet, Fat-Restricted; Insulin; Insulin Resistance; Phenotype; Adult; Middle Aged; Aged; 0601 Biochemistry and Cell Biology; 1101 Medical Biochemistry and Metabolomics; Endocrinology & Metabolism |
| Subjects: | T Technology > TX Home economics > TX341 Nutrition. Foods and food supply Q Science > QH Natural history > QH301 Biology R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Elsevier |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 02 Mar 2023 10:23 |
| Last Modified: | 02 Mar 2023 10:30 |
| DOI or ID number: | 10.1016/j.cmet.2022.12.002 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/18983 |
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