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De Koning, IA, Van Bakel, BMA, Rotbi, H, Van Geuns, RJM, Cramer, GE, Pop, GAM, Eijsvogels, T and Thijssen, DHJ (2023) Association between engagement in exercise training and peak cardiac biomarker concentrations following ST-elevation myocardial infarction. BMJ Open Sport and Exercise Medicine, 9 (2). ISSN 2055-7647
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Association between engagement in exercise training and peak cardiac biomarker concentrations following ST-elevation myocardial infarction.pdf - Published Version Available under License Creative Commons Attribution Non-commercial. Download (637kB) | Preview |
Abstract
Background: Regular exercise training is an important factor in prevention of myocardial infarction (MI). However, little is known whether exercise engagement prior to MI is related to the magnitude of post-MI cardiac biomarker concentrations and clinical outcomes. Objectives: We tested the hypothesis that exercise engagement in the week prior MI is related to lower cardiac biomarker concentrations following ST-elevated MI (STEMI). Methods We recruited hospitalised STEMI patients and assessed the amount of exercise engagement in the 7 days preceding MI onset using a validated questionnaire. Patients were classified as 'exercise' if they performed any vigorous exercise in the week prior MI, or as 'control' if they did not. Post-MI peak concentrations of high-sensitive cardiac troponin T (peak-hs-cTnT) and creatine kinase (peak-CK) were examined. We also explored whether exercise engagement prior MI is related to the clinical course (duration of hospitalisation and incidence of in-hospital, 30-day and 6-month major adverse cardiac events (reinfarction, target vessel revascularisation, cardiogenic shock or death)).
Results: In total, 98 STEMI patients were included, of which 16% (n=16) was classified as 'exercise', and 84% (n=82) as 'control'. Post-MI peak-hs-cTnT and peak-CK concentrations were lower in the exercise group (941 (645-2925) ng/mL; 477 (346-1402) U/L, respectively) compared with controls (3136 (1553-4969) ng/mL, p=0.010; 1055 (596-2019) U/L, p=0.016, respectively). During follow-up, no significant differences were found between both groups. Conclusion: Engagement in exercise is associated with lower cardiac biomarker peak concentrations following STEMI. These data could provide further support for the cardiovascular health benefits of exercise training.
| Item Type: | Article |
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| Uncontrolled Keywords: | 1106 Human Movement and Sports Sciences |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | BMJ |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 04 Jul 2023 09:41 |
| Last Modified: | 04 Jul 2023 09:45 |
| DOI or ID number: | 10.1136/bmjsem-2022-001488 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/20209 |
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