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Rahimi, MR, Semenova, EA, Larin, AK, Kulemin, NA, Generozov, EV, Łubkowska, B, Ahmetov, II and Golpasandi, H (2023) The ADORA2A TT Genotype Is Associated with Anti-Inflammatory Effects of Caffeine in Response to Resistance Exercise and Habitual Coffee Intake. Nutrients, 15 (7). ISSN 2072-6643
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The iADORA2Ai TT Genotype Is Associated with Anti-Inflammatory Effects of Caffeine in Response to Resistance Exercise and Ha.pdf - Published Version Available under License Creative Commons Attribution. Download (760kB) | Preview |
Abstract
Caffeine is an adenosine A2A receptor (ADORA2A) antagonist with ergogenic and anti-inflammatory effects. Previous studies have reported that the ADORA2A gene regulates glutamate metabolism and immune responses, with the ADORA2A rs5751876 TT genotype (with high sensitivity to caffeine) showing larger ergogenic effect following caffeine ingestion. We therefore hypothesized that the TT genotype would be associated with greater anti-inflammatory effects of caffeine in response to exercise, and with higher coffee intake in physically active individuals. The aim of the present study was twofold: (1) to investigate the association of the ADORA2A variant with the anti-inflammatory effects of caffeine in response to intense resistance exercise (RE), and (2) to analyze the association of the rs5751876 with coffee intake in physically active individuals (n = 134). Fifteen resistance-trained athletes participated in a randomized, double-blind, placebo-controlled cross-over study, where they consumed 6 mg/kg of caffeine or placebo one hour prior to performing an RE protocol. Blood samples were taken immediately from the arterial vein before, immediately after, and 15 min after RE for the analysis of inflammatory markers myeloperoxidase (MPO) and acetylcholinesterase (AChE). We found that the ADORA2A TT genotype carriers experienced lower exercise-induced inflammatory responses (p < 0.05 for AchE) when compared to the C allele carriers (i.e., CC/CT) one hour following the ingestion of caffeine. Furthermore, the ADORA2A TT genotype was positively associated with coffee intake (p = 0.0143; irrespective of CYP1A2 rs762551 polymorphism). In conclusion, we found that the ADORA2A gene polymorphism is associated with anti-inflammatory effects of caffeine in response to resistance exercise, as well as with habitual coffee intake in physically active individuals.
| Item Type: | Article |
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| Uncontrolled Keywords: | Humans; Caffeine; Cytochrome P-450 CYP1A2; Acetylcholinesterase; Receptor, Adenosine A2A; Anti-Inflammatory Agents; Cross-Over Studies; Genotype; Heterozygote; Coffee; Resistance Training; adenosine; immune system; inflammation; neutrophils; performance; sports; strength; training; Humans; Caffeine; Receptor, Adenosine A2A; Coffee; Cross-Over Studies; Resistance Training; Acetylcholinesterase; Heterozygote; Anti-Inflammatory Agents; Cytochrome P-450 CYP1A2; Genotype; 0908 Food Sciences; 1111 Nutrition and Dietetics |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | MDPI AG |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 21 Jul 2023 15:06 |
| Last Modified: | 21 Jul 2023 15:15 |
| DOI or ID number: | 10.3390/nu15071634 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/20477 |
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