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Exposure considerations in human safety assessment: Report from an EPAA Partners’ Forum

Cronin, MTD, Ball, N, Beken, S, Bender, H, Bercaru, O, Caneva, L, Corvaro, M, Currie, RA, Dawson, JL, Desert, P, Escher, SE, Franco, A, Irizar, A, Mehta, JM, Rogiers, V, Tremblay, RT, Westmoreland, C and Maxwell, G (2023) Exposure considerations in human safety assessment: Report from an EPAA Partners’ Forum. Regulatory Toxicology and Pharmacology, 144. ISSN 0273-2300

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Understanding and estimating the exposure to a substance is one of the fundamental requirements for safe manufacture and use. Many approaches are taken to determine exposure to substances, mainly driven by potential use and regulatory need. There are many opportunities to improve and optimise the use of exposure information for chemical safety. The European Partnership for Alternative Approaches to Animal Testing (EPAA) therefore convened a Partners’ Forum (PF) to explore exposure considerations in human safety assessment of industrial products to agree key conclusions for the regulatory acceptance of exposure assessment approaches; and priority areas for further research investment. The PF recognised the widescale use of exposure information across industrial sectors with the possibilities creating synergies between different sectors. Further, the PF acknowledged that the EPAA could make a significant contribution to promote the use of exposure data in human safety assessment, with an aim to address specific regulatory needs. To achieve this, research needs as well as synergies and areas for potential collaboration across sectors were identified.

Item Type: Article
Uncontrolled Keywords: 1115 Pharmacology and Pharmaceutical Sciences; Toxicology
Subjects: R Medicine > RA Public aspects of medicine > RA1190 Toxicology. Poisions
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier BV
SWORD Depositor: A Symplectic
Date Deposited: 30 Aug 2023 14:45
Last Modified: 15 Feb 2024 14:45
DOI or ID number: 10.1016/j.yrtph.2023.105483
URI: https://researchonline.ljmu.ac.uk/id/eprint/20994
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