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Ultrasound-Mediated Ocular Drug Delivery: From Physics and Instrumentation to Future Directions

Duncan, B, Al-Kassas, R, Zhang, G, Hughes, D and Qiu, Y (2023) Ultrasound-Mediated Ocular Drug Delivery: From Physics and Instrumentation to Future Directions. Micromachines, 14 (8). ISSN 2072-666X

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<jats:p>Drug delivery to the anterior and posterior segments of the eye is impeded by anatomical and physiological barriers. Increasingly, the bioeffects produced by ultrasound are being proven effective for mitigating the impact of these barriers on ocular drug delivery, though there does not appear to be a consensus on the most appropriate system configuration and operating parameters for this application. In this review, the fundamental aspects of ultrasound physics most pertinent to drug delivery are presented; the primary phenomena responsible for increased drug delivery efficacy under ultrasound sonication are discussed; an overview of common ocular drug administration routes and the associated ocular barriers is also given before reviewing the current state of the art of ultrasound-mediated ocular drug delivery and its potential future directions.</jats:p>

Item Type: Article
Uncontrolled Keywords: acoustic cavitation; acoustic streaming; ocular barriers; ocular drug delivery; targeted drug delivery; ultrasound; 1007 Nanotechnology
Subjects: R Medicine > RS Pharmacy and materia medica
T Technology > T Technology (General)
Divisions: Engineering
Pharmacy & Biomolecular Sciences
Publisher: MDPI AG
SWORD Depositor: A Symplectic
Date Deposited: 30 Aug 2023 15:10
Last Modified: 30 Aug 2023 15:15
DOI or ID number: 10.3390/mi14081575
URI: https://researchonline.ljmu.ac.uk/id/eprint/21020
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