Hale, MR, Langhough, R, Du, L, Hermann, BP, Van Hulle, CA, Carboni, M, Kollmorgen, G, Basche, KE, Bruno, D, Sanson-Miles, L, Jonaitis, EM, Chin, NA, Okonkwo, OC, Bendlin, BB, Carlsson, CM, Zetterberg, H, Blennow, K, Betthauser, TJ, Johnson, SC and Mueller, KD (2023) Associations between recall of proper names in story recall and CSF amyloid and tau in adults without cognitive impairment. Neurobiology of Aging, 133. pp. 87-98. ISSN 0197-4580

Text Associations between recall of proper names in story recall and CSF amyloid and tau in adults without cognitive impairment.pdf - Accepted Version Restricted to Repository staff only until 5 October 2024. Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (924kB)

Abstract

Neuropsychological measures sensitive to decline in the preclinical phase of Alzheimer’s disease (AD) are needed. We previously demonstrated that higher amyloid-beta (Aβ) assessed by positron emission tomography in adults without cognitive impairment was associated with recall of fewer proper names in Logical Memory story recall. The current study investigated the association between proper names and cerebrospinal fluid (CSF) biomarkers (Aβ42/40, phosphorylated tau181, (pTau181), neurofilament light) in 223 participants from the Wisconsin Registry for Alzheimer’s Prevention. We assessed associations between biomarkers and delayed Logical Memory total score and proper names using binary logistic regressions. Sensitivity analyses used multinomial logistic regression and stratified biomarker groups. Lower Logical Memory total score and proper names scores from most recent visit were associated with biomarker positivity. Relatedly, there was a 27% decreased risk of being classified Aβ42/40+/pTau181+ for each additional proper name recalled. A linear mixed effects model found that longitudinal change in proper names recall was predicted by biomarker status. These results demonstrate a novel relationship between proper names and AD-CSF pathology.

Item Type:	Article
Uncontrolled Keywords:	1103 Clinical Sciences; 1109 Neurosciences; Neurology & Neurosurgery
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Psychology (from Sep 2019)
Publisher:	Elsevier
SWORD Depositor:	A Symplectic
Date Deposited:	09 Oct 2023 10:59
Last Modified:	07 Nov 2023 16:00
DOI or ID number:	10.1016/j.neurobiolaging.2023.09.018
URI:	https://researchonline.ljmu.ac.uk/id/eprint/21694

View Item