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Menopausal stage differences in endothelial resistance to ischemia-reperfusion injury

Delgado Spicuzza, JM, Proctor, DN, Thijssen, DHJ and Somani, YB (2023) Menopausal stage differences in endothelial resistance to ischemia-reperfusion injury. Physiological Reports, 11 (18). ISSN 2051-817X

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Background: In postmenopausal women, reduced ovarian function precedes endothelial dysfunction and attenuated endothelial resistance to ischemia-reperfusion (IR) injury. We hypothesized that IR injury would lower endothelial function, with premenopausal women demonstrating the greatest protection from injury, followed by early, then late postmenopausal women. Methods: Flow-mediated dilation (FMD) was assessed at baseline and following IR injury in premenopausal (n = 11), early (n = 11; 4 ± 1.6 years since menopause), and late (n = 11; 15 ± 5.5 years since menopause) postmenopausal women. Results: There were significant group differences in baseline FMD (p = 0.007); post hoc analysis revealed a similar resting FMD between premenopausal (7.8% ± 2.1%) and early postmenopausal (7.1% ± 2.7%), but significantly lower FMD in late postmenopausal women (4.5% ± 2.3%). Results showed an overall decline in FMD after IR injury (p < 0.001), and a significant condition*time interaction (p = 0.048), with early postmenopausal women demonstrating the most significant decline in FMD following IR. Conclusion: Our findings indicate that endothelial resistance to IR injury is attenuated in healthy early postmenopausal women.

Item Type: Article
Uncontrolled Keywords: Humans; Reperfusion Injury; Health Status; Menopause; Rest; Female; Female; Humans; Menopause; Reperfusion Injury; Health Status; Rest; 0606 Physiology; 1103 Clinical Sciences; 1116 Medical Physiology
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
R Medicine > RG Gynecology and obstetrics
Divisions: Sport & Exercise Sciences
Publisher: Wiley Open Access
SWORD Depositor: A Symplectic
Date Deposited: 07 Nov 2023 10:46
Last Modified: 07 Nov 2023 10:46
DOI or ID number: 10.14814/phy2.15768
URI: https://researchonline.ljmu.ac.uk/id/eprint/21805
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