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Central and local arterial stiffness in White Europeans compared to age-, sex-, and BMI-matched South Asians

van Der Sluijs, KM, Thannhauser, J, Visser, IM, Nabeel, PM, Raj, KV, Malik, AEF, Reesink, KD, Eijsvogels, TMH, Bakker, EA, Kaur, P, Joseph, J and Thijssen, DHJ (2023) Central and local arterial stiffness in White Europeans compared to age-, sex-, and BMI-matched South Asians. PLoS One, 18. ISSN 1932-6203

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Background Ethnicity impacts cardiovascular disease (CVD) risk, and South Asians demonstrate a higher risk than White Europeans. Arterial stiffness is known to contribute to CVD, and differences in arterial stiffness between ethnicities could explain the disparity in CVD risk. We compared central and local arterial stiffness between White Europeans and South Asians and investigated which factors are associated with arterial stiffness. Methods Data were collected from cohorts of White Europeans (the Netherlands) and South Asians (India). We matched cohorts on individual level using age, sex, and body mass index (BMI). Arterial stiffness was measured with ARTSENS® Plus. Central stiffness was expressed as carotid-femoral pulse wave velocity (cf-PWV, m/s), and local carotid stiffness was quantified using the carotid stiffness index (Beta) and pressure-strain elastic modulus (Epsilon, kPa). We compared arterial stiffness between cohorts and used multivariable linear regression to identify factors related to stiffness. Results We included n = 121 participants per cohort (age 53±10 years, 55% male, BMI 24 kg/m2). Cf-PWV was lower in White Europeans compared to South Asians (6.8±1.9 vs. 8.2±1.8 m/s, p<0.001), but no differences were found for local stiffness parameters Beta (5.4±2.4 vs. 5.8 ±2.3, p = 0.17) and Epsilon (72±35 vs. 70±31 kPa, p = 0.56). Age (standardized β, 95% confidence interval: 0.28, 0.17-0.39), systolic blood pressure (0.32, 0.21-0.43), and South Asian ethnicity (0.46, 0.35-0.57) were associated with cf-PWV; associations were similar between cohorts (p>0.05 for interaction). Systolic blood pressure was associated with carotid stiffness in both cohorts, whereas age was associated to carotid stiffness only in South Asians and BMI only in White Europeans. Conclusion Ethnicity is associated with central but not local arterial stiffness. Conversely, ethnicity seems to modify associations between CVD risk factors and local but not central arterial stiffness. This suggests that ethnicity interacts with arterial stiffness measures and the association of these measures with CVD risk factors.

Item Type: Article
Uncontrolled Keywords: Humans; Cardiovascular Diseases; Body Mass Index; Age Factors; Sex Factors; Adult; Middle Aged; India; Netherlands; Female; Male; Vascular Stiffness; Pulse Wave Analysis; White People; South Asian People; Adult; Female; Humans; Male; Middle Aged; Body Mass Index; Cardiovascular Diseases; Pulse Wave Analysis; South Asian People; Vascular Stiffness; White People; Age Factors; Sex Factors; Netherlands; India; General Science & Technology
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Public Library of Science
SWORD Depositor: A Symplectic
Date Deposited: 07 Nov 2023 11:36
Last Modified: 07 Nov 2023 11:45
DOI or ID number: 10.1371/journal.pone.0290118
Editors: Pucci, G
URI: https://researchonline.ljmu.ac.uk/id/eprint/21806
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