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Srivastava, P, Nabeel, PM, Raj, KV, Soneja, M, Chandran, DS, Joseph, J, Wig, N, Jaryal, AK, Thijssen, DHJ and Deepak, KK (2023) Baroreflex sensitivity is impaired in survivors of mild COVID-19 at 3-6 months of clinical recovery; association with carotid artery stiffness. Physiological reports, 11 (21). pp. 1-14. ISSN 2051-817X
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Baroreflex sensitivity is impaired in survivors of mild COVID-19 at 3-6 months of clinical recovery; association with caroti.pdf - Published Version Available under License Creative Commons Attribution. Download (2MB) | Preview |
Abstract
The association between the stiffening of barosensitive regions of central arteries and the derangements in baroreflex functions remains unexplored in COVID-19 survivors. Fifty-seven survivors of mild COVID-19 (defined as presence of upper respiratory tract symptoms and/or fever without shortness of breath or hypoxia; SpO2 > 93%), with an age range of 22-66 years (27 females) participated at 3-6 months of recovering from the acute phase of RT-PCR positive COVID-19. Healthy volunteers whose baroreflex sensitivity (BRS) and arterial stiffness data were acquired prior to the onset of the pandemic constituted the control group. BRS was found to be significantly lower in the COVID survivor group for the systolic blood pressure-based sequences (BRS SBP ) [9.78 (7.16-17.74) ms/mmHg vs 16.5 (11.25-23.78) ms/mmHg; p = 0.0253]. The COVID survivor group showed significantly higher carotid β stiffness index [7.16 (5.75-8.18) vs 5.64 (4.34-6.96); (p = 0.0004)], and pulse wave velocity β (PWVβ ) [5.67 (4.96-6.32) m/s vs 5.12 (4.37-5.41) m/s; p = 0.0002]. BRS quantified by both the sequence and spectral methods showed an inverse correlation with PWVβ in the male survivors. Impairment of BRS in the male survivors of mild COVID-19 at 3-6 months of clinical recovery shows association with carotid artery stiffness.
| Item Type: | Article |
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| Uncontrolled Keywords: | Carotid Arteries; Humans; Blood Pressure; Heart Rate; Baroreflex; Child, Preschool; Infant; Female; Male; Vascular Stiffness; Pulse Wave Analysis; COVID-19; Female; Humans; Male; Infant; Child, Preschool; Baroreflex; Pulse Wave Analysis; COVID-19; Carotid Arteries; Blood Pressure; Vascular Stiffness; Heart Rate; 0606 Physiology; 1103 Clinical Sciences; 1116 Medical Physiology |
| Subjects: | Q Science > QP Physiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Wiley |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 07 Nov 2023 11:46 |
| Last Modified: | 07 Nov 2023 12:00 |
| DOI or ID number: | 10.14814/phy2.15845 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/21807 |
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