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Yang, C, Rathman, JF, Ribeiro, V, Batke, M, Escher, SE, Firman, JW, Hobocienski, B, Kellner, R, Mostrag, A, Przybylak, KR and Cronin, MTD (2023) Update of the Cancer Potency Database (CPDB) to enable derivations of Thresholds Of Toxicological Concern (TTC) for cancer potency. Food and Chemical Toxicology, 182. ISSN 0278-6915
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Update of the Cancer Potency Database CPDB to enable derivations of Thresholds of Toxicological Concern TTC for cancer potency.pdf - Published Version Available under License Creative Commons Attribution. Download (5MB) | Preview |
Abstract
The purpose of this study was to update the existing Cancer Potency Database (CPDB) in order to support the development of a dataset of compounds, with associated points of departure (PoDs), to enable a review and update of currently applied values for the Threshold of Toxicological Concern (TTC) for cancer endpoints. This update of the current CPDB, last reviewed in 2012, includes the addition of new data (44 compounds and 158 studies leading to additional 359 dose-response curves). Strict inclusion criteria were established and applied to select compounds and studies with relevant cancer potency data. PoDs were calculated from dose-response modeling, including the benchmark dose (BMD) and the lower 90% confidence limits (BMDL) at a specified benchmark response (BMR) of 10%. The updated full CPDB database resulted in a total of 421 chemicals which had dose-response data that could be used to calculate PoDs. This candidate dataset for cancer TTC is provided in a transparent and adaptable format for further analysis of TTC to derive cancer potency thresholds.
| Item Type: | Article |
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| Uncontrolled Keywords: | 0908 Food Sciences; Food Science |
| Subjects: | R Medicine > RA Public aspects of medicine > RA1190 Toxicology. Poisions R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Elsevier |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 10 Nov 2023 10:38 |
| Last Modified: | 24 Nov 2023 10:45 |
| DOI or ID number: | 10.1016/j.fct.2023.114182 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/21845 |
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