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Weijs, RW, Oudegeest-Sander, MH, Hopman, MT, Thijssen, DH and Claassen, JA (2023) Cerebrovascular CO2 reactivity and dynamic cerebral autoregulation through the eighth decade of life and their implications for cognitive decline. Journal of Cerebral Blood Flow & Metabolism. pp. 1-14. ISSN 0271-678X
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Cerebrovascular CO2 reactivity and dynamic cerebral autoregulation through the eighth decade of life and their implications for cognitive decline.pdf - Published Version Available under License Creative Commons Attribution Non-commercial. Download (715kB) | Preview |
Abstract
Aging is accompanied by a decrease in cerebral blood flow (CBF), especially in the presence of preclinical cognitive decline. The role of cerebrovascular physiology including regulatory mechanisms of CBF in processes underlying aging and subclinical cognitive decline is, however, not fully understood. We explored changes in cerebrovascular CO2 reactivity and dynamic cerebral autoregulation (dCA) through the eighth decade of life, and their relation with early cognitive decline. After 10.9 years, twenty-eight (age, 80.0 ± 3.5 years; 46% female) out of forty-eight healthy older adults who had participated in a previous study (age at baseline, 70 ± 4 years; 42% female), underwent repeated transcranial Doppler assessments. Linear mixed-model analyses revealed small reductions in cerebrovascular CO2 reactivity with aging (-0.37%/mmHg, P = 0.041), whereas dCA was modestly enhanced (gain: -0.009 cm/s/mmHg, P = 0.038; phase: +8.9 degrees, P = 0.004). These changes were more pronounced in participants who had developed subjective memory complaints at follow-up. Our observations confirm that dCA is not impaired in aging, despite lower cerebral perfusion and cerebrovascular reactivity. Altogether, this unique longitudinal study highlights the involvement of cerebrovascular health in preclinical cognitive decline, which is of clinical relevance in the development of dementia management strategies.
| Item Type: | Article |
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| Uncontrolled Keywords: | Aged; brain blood flow; cognition; dementia; longitudinal studies; 1102 Cardiorespiratory Medicine and Haematology; 1103 Clinical Sciences; 1109 Neurosciences; Neurology & Neurosurgery |
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | SAGE Publications |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 19 Dec 2023 14:51 |
| Last Modified: | 19 Dec 2023 15:00 |
| DOI or ID number: | 10.1177/0271678x231219568 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/22130 |
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