Mogoko, G, Imam, S, Rahman, K and Babafemi, E (2023) Mycobacterium Chelonae Line Sepsis in a 4-Year-Old Male with Acute Myeloid Leukaemia (AML). Annals of Clinical and Medical Case Reports, 12 (5). pp. 1-4.

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Abstract

Background: Mycobacterium chelonae (MC) was isolated from an immunosuppressed four-year-old with Acute Myeloid Leukaemia. This was initially dismissed as gram positive bacil li diptheroid based on gram staining. Several more blood culture bottles flagged up positive in quick succession. A review of the gram stain with additional ZN staining revealed acid-fast bacilli and finally identified as Mycobacterium chelonae. Case Presentation: a 4-year-old (now 5) male with acute myeloid leukaemia presented to Emergency department at Sou thend hospital with febrile non-neutropenia/low grade fever, loss of appetite, weight loss and general weakness. Suspected Sore and infected gastrostomy site, with percutaneous endoscopic gas trostomy (PEG). Blood cultures were collected and patient put-on broad-spectrum antibiotics and antifungal. 5 sets yielded Myco bacterium chelonae. The patient was kept on broad spectrum anti biotics with additional meropenem, removal of PEG and follow up blood cultures were negative. Conclusion: Nontuberculous mycobacteria, particularly fast growers, should be considered or excluded by ZN staining in pos itive cultures after 2-4 days from immunosuppressed patients with gram positive rods (GPRs) on gram staining, thisis even more necessary if patients have lines insitu. Several multiple sets of blood culture will also be helpful to rule out contamination. Laboratories should attempt to identify NTM by Matrix Assisted Laser Desorp tion-Time of Flight (MALDI-TOF) by full extraction if available. If the isolate is considered clinically significant, a full antibiotic susceptibility should be sought to guide therapy.

Item Type:	Article
Uncontrolled Keywords:	Fast growers; Iimmunosuppressed; Acute myeloid; Leukemia; Line; Myeloblasts
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy & Biomolecular Sciences
Publisher:	United Prime Publications L.L.C
SWORD Depositor:	A Symplectic
Date Deposited:	04 Jan 2024 14:08
Last Modified:	04 Jan 2024 14:08
URI:	https://researchonline.ljmu.ac.uk/id/eprint/22189

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