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Association of latent factors of neuroinflammation with Alzheimer's disease pathology and longitudinal cognitive decline

Teipel, SJ, Dyrba, M, Kleineidam, L, Brosseron, F, Levin, F, Bruno, D, Buerger, K, Cosma, N, Schneider, LS, Düzel, E, Glanz, W, Fliessbach, K, Janowitz, D, Kilimann, I, Laske, C, Munk, MH, Maier, F, Peters, O, Pomara, N, Perneczky, R , Rauchmann, BS, Priller, J, Ramirez, A, Roy, N, Schneider, A, Spottke, A, Spruth, EJ, Roeske, S, Wagner, M, Wiltfang, J, Wolfsgruber, S, Bartels, C, Jessen, F and Heneka, MT (2024) Association of latent factors of neuroinflammation with Alzheimer's disease pathology and longitudinal cognitive decline. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 16 (1). pp. 1-12.

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INTRODUCTION: We investigated the association of inflammatory mechanisms with markers of Alzheimer's disease (AD) pathology and rates of cognitive decline in the AD spectrum. METHODS: We studied 296 cases from the Deutsches Zentrum für Neurodegenerative Erkrankungen Longitudinal Cognitive Impairment and Dementia Study (DELCODE) cohort, and an extension cohort of 276 cases of the Alzheimer's Disease Neuroimaging Initiative study. Using Bayesian confirmatory factor analysis, we constructed latent factors for synaptic integrity, microglia, cerebrovascular endothelial function, cytokine/chemokine, and complement components of the inflammatory response using a set of inflammatory markers in cerebrospinal fluid. RESULTS: We found strong evidence for an association of synaptic integrity, microglia response, and cerebrovascular endothelial function with a latent factor of AD pathology and with rates of cognitive decline. We found evidence against an association of complement and cytokine/chemokine factors with AD pathology and rates of cognitive decline. DISCUSSION: Latent factors provided access to directly unobservable components of the neuroinflammatory response and their association with AD pathology and cognitive decline.

Item Type: Article
Uncontrolled Keywords: 0604 Genetics; 1109 Neurosciences
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Psychology (from Sep 2019)
Publisher: Wiley
SWORD Depositor: A Symplectic
Date Deposited: 09 Feb 2024 14:19
Last Modified: 09 Feb 2024 14:30
DOI or ID number: 10.1002/dad2.12510
URI: https://researchonline.ljmu.ac.uk/id/eprint/22578
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