Abdellatif, AAH, Scagnetti, G, Younis, MA, Bouazzaoui, A, Tawfeek, HM, Aldosari, BN, Almurshedi, AS, Alsharidah, M, Rugaie, OA, Davies, MPA, Liloglou, T, Ross, K and Saleem, I (2023) Non-coding RNA-directed therapeutics in lung cancer: Delivery technologies and clinical applications. Colloids and Surfaces B: Biointerfaces, 229. pp. 1-17. ISSN 0927-7765

	Text Non-coding RNADirected Therapeutics in Lung Cancer Delivery Technologies and Clinical Applications.pdf - Accepted Version Restricted to Repository staff only until 18 July 2024. Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (424kB)
	Text Tables-June .pdf - Accepted Version Restricted to Repository staff only until 18 July 2024. Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (142kB)
	Text Figures-June 2023.pdf - Accepted Version Restricted to Repository staff only until 18 July 2024. Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (726kB)

Abstract

Lung cancer is one of the most aggressive and deadliest health threats. There has been an increasing interest in non-coding RNA (ncRNA) recently, especially in the areas of carcinogenesis and tumour progression. However, ncRNA-directed therapies are still encountering obstacles on their way to the clinic. In the present article, we provide an overview on the potential of targeting ncRNA in the treatment of lung cancer. Then, we discuss the delivery challenges and recent approaches enabling the delivery of ncRNA-directed therapies to the lung cancer cells, where we illuminate some advanced technologies including chemically-modified oligonucleotides, nuclear targeting, and three-dimensional in vitro models. Furthermore, advanced non-viral delivery systems recruiting nanoparticles, biomimetic delivery systems, and extracellular vesicles are also highlighted. Lastly, the challenges limiting the clinical trials on the therapeutic targeting of ncRNAs in lung cancer and future directions to tackle them are explored.

Item Type:	Article
Uncontrolled Keywords:	Humans; Lung Neoplasms; RNA, Untranslated; Molecular Targeted Therapy; Carcinogenesis; Lung cancer; Nanocarriers; Non-coding RNA; Oligonucleotides; Humans; RNA, Untranslated; Lung Neoplasms; Carcinogenesis; Molecular Targeted Therapy; 0306 Physical Chemistry (incl. Structural); 0903 Biomedical Engineering; 0904 Chemical Engineering; Chemical Physics
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy & Biomolecular Sciences
Publisher:	Elsevier
SWORD Depositor:	A Symplectic
Date Deposited:	02 Apr 2024 12:01
Last Modified:	02 Apr 2024 12:01
DOI or ID number:	10.1016/j.colsurfb.2023.113466
URI:	https://researchonline.ljmu.ac.uk/id/eprint/22937

View Item