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Atrial fibrillation: pathophysiology, genetic and epigenetic mechanisms

Vinciguerra, M, Dobrev, D and Nattel, S (2024) Atrial fibrillation: pathophysiology, genetic and epigenetic mechanisms. The Lancet Regional Heath Europe, 37. pp. 1-17. ISSN 2666-7762

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Atrial fibrillation (AF) is the most common supraventricular arrhythmia affecting up to 1% of the general population. Its prevalence dramatically increases with age and could reach up to ∼10% in the elderly. The management of AF is a complex issue that is object of extensive ongoing basic and clinical research, it depends on its genetic and epigenetic causes, and it varies considerably geographically and also according to the ethnicity. Mechanistically, over the last decade, Genome Wide Association Studies have uncovered over 100 genetic loci associated with AF, and have shown that European ancestry is associated with elevated risk of AF. These AF-associated loci revolve around different types of disturbances, including inflammation, electrical abnormalities, and structural remodeling. Moreover, the discovery of epigenetic regulatory mechanisms, involving non-coding RNAs, DNA methylation and histone modification, has allowed unravelling what modifications reshape the processes leading to arrhythmias. Our review provides a current state of the field regarding the identification and functional characterization of AF-related genetic and epigenetic regulatory networks, including ethnic differences. We discuss clear and emerging connections between genetic regulation and pathophysiological mechanisms of AF.

Item Type: Article
Uncontrolled Keywords: Atrial fibrillation; Epigenetics; Genetics; Mechanisms
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
SWORD Depositor: A Symplectic
Date Deposited: 05 Apr 2024 12:14
Last Modified: 05 Apr 2024 12:15
DOI or ID number: 10.1016/j.lanepe.2023.100785
URI: https://researchonline.ljmu.ac.uk/id/eprint/22961
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