Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

Reducing temperature of fused deposition modelling 3D printing for linalool fast dissolving oral films by increasing printer nozzle diameter

Ehtezazi, T, Kteich, A, Abdulkarim, R, Anderson, V, Algellay, M, McCloskey, AP, Carter, N, Roberts, M, Assi, S, Al-Jumeily, D, Thompson, M, Mohamed, FA and Sarker, SD (2024) Reducing temperature of fused deposition modelling 3D printing for linalool fast dissolving oral films by increasing printer nozzle diameter. Journal of Pharmaceutical Sciences. ISSN 0022-3549

[img] Text
Reducing Temperature of Fused Deposition Modelling 3D Printing for Linalool Fast Dissolving Oral Films by Increasing Printer Nozzle Diameter.pdf - Accepted Version
Restricted to Repository staff only until 13 April 2025.
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (172kB)


Oral thrush and throat infections can occur in a wide range of patients. Treatments are available; however, resistance to drugs is a major problem for treating oral and throat infections. Three-dimensional printing (3DP) of fast dissolving oral films (FDFs) of linalool oil may provide an alternative solution. Linalool oil FDFs were printed by fused deposition modelling across 1-18% w/w linalool content range with nozzle diameters of 0.4 or 1 mm at the temperature range of 150C-185C. The FDFs were evaluated for physicochemical and mechanical properties. Increasing the printer nozzle diameter to 1 mm allowed reducing the printing temperature from 185C to 150C; consequently, more linalool was quantified in the films with improved content uniformity. The higher linalool content in the films increased the film disintegration time and mechanical strength. FDFs containing 10% w/w linalool showed clear antifungal activity against Candida albicans. Raman spectroscopy suggested linalool separation from excipients at higher temperature printing. Viscoelastic measurements indicated that to achieve printing; the elastic modulus of molten filament needed to be higher than the loss modulus at low angular frequencies. In conclusion, increasing the printing nozzle diameter may avoid loss of the active ingredient by reducing the temperature of the 3DP process.

Item Type: Article
Uncontrolled Keywords: 1115 Pharmacology and Pharmaceutical Sciences; Pharmacology & Pharmacy
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
SWORD Depositor: A Symplectic
Date Deposited: 12 Apr 2024 09:45
Last Modified: 28 Apr 2024 15:00
DOI or ID number: 10.1016/j.xphs.2024.04.008
URI: https://researchonline.ljmu.ac.uk/id/eprint/23018
View Item View Item