Ahmetov, II, Mozhayskaya, IA, Flavell, DM, Astratenkova, IV, Lyubaeva, EV, Shenkman, BS, Vdovina, AB, Netreba, AI, Popov, DV, Vinogradova, OL, Montgomery, HE and Rogozkin, VA (2006) PPARα gene variation and physical performance in Russian athletes. European Journal of Applied Physiology, 97 (1). pp. 103-108. ISSN 1439-6319

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Abstract

Peroxisome proliferator-activated receptor α (PPARα) regulates genes responsible for skeletal and heart muscle fatty acid oxidation. Previous studies have shown that the PPARα intron 7 G/C polymorphism was associated with left ventricular growth in response to exercise. We speculated that GG homozygotes should be more prevalent within a group of endurance-oriented athletes, have normal fatty acid metabolism, and increased percentages of slow-twitch fibers. We have tested this hypothesis in the study of a mixed cohort of 786 Russian athletes in 13 different sporting disciplines prospectively stratified by performance (endurance-oriented athletes, power-oriented athletes and athletes with mixed endurance/power activity). PPARα intron 7 genotype and allele frequencies were compared to 1,242 controls. We found an increasing linear trend of C allele with increasing anaerobic component of physical performance (P=0.029). GG genotype frequencies in endurance-oriented and power-oriented athletes were 80.3 and 50.6%, respectively, and were significantly (P<0.0001) different compared to controls (70.0%). To examine the association between PPARα gene variant and fiber type composition, muscle biopsies from m. vastus lateralis were obtained and analyzed in 40 young men. GG homozygotes (n=25) had significantly (P=0.003) higher percentages of slow-twitch fibers (55.5±2.0 vs 38.5±2.3%) than CC homozygotes (n=4). In conclusion, PPARα intron 7 G/C polymorphism was associated with physical performance in Russian athletes, and this may be explained, in part, by the association between PPARα genotype and muscle fiber type composition. © Springer-Verlag 2006.

Item Type:	Article
Additional Information:	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00421-006-0154-4
Uncontrolled Keywords:	Science & Technology; Life Sciences & Biomedicine; Physiology; Sport Sciences; PPAR alpha; polymorphism; fatty acids; muscle fiber type; physical performance; PROLIFERATOR-ACTIVATED RECEPTOR; PROGRESSION; EXPRESSION; EXERCISE; GAMMA; Muscle, Skeletal; Humans; PPAR alpha; Psychomotor Performance; Physical Endurance; Sports; Adult; Russia; Female; Male; Genetic Variation; Adult; Female; Genetic Variation; Humans; Male; Muscle, Skeletal; PPAR alpha; Physical Endurance; Psychomotor Performance; Russia; Sports; 1106 Human Movement and Sports Sciences; Sport Sciences
Subjects:	R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Screen School
Publisher:	SPRINGER
SWORD Depositor:	A Symplectic
Date Deposited:	22 Apr 2024 15:27
Last Modified:	22 Apr 2024 15:30
DOI or ID number:	10.1007/s00421-006-0154-4
URI:	https://researchonline.ljmu.ac.uk/id/eprint/23056

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