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Rankinen, T, Fuku, N, Wolfarth, B, Wang, G, Sarzynski, MA, Alexeev, DG, Ahmetov, II, Boulay, MR, Cieszczyk, P, Eynon, N, Filipenko, ML, Garton, FC, Generozov, EV, Govorun, VM, Houweling, PJ, Kawahara, T, Kostryukova, ES, Kulemin, NA, Larin, AK, Maciejewska-Karłowska, A , Miyachi, M, Muniesa, CA, Murakami, H, Ospanova, EA, Padmanabhan, S, Pavlenko, AV, Pyankova, ON, Santiago, C, Sawczuk, M, Scott, RA, Uyba, VV, Yvert, T, Perusse, L, Ghosh, S, Rauramaa, R, North, KN, Lucia, A, Pitsiladis, Y and Bouchard, C (2016) No evidence of a common DNA variant profile specific to world class endurance athletes. PLoS One, 11 (1). ISSN 1932-6203
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No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes.pdf - Published Version Available under License Creative Commons Attribution. Download (2MB) | Preview |
Abstract
There are strong genetic components to cardiorespiratory fitness and its response to exercise training. It would be useful to understand the differences in the genomic profile of highly trained endurance athletes of world class caliber and sedentary controls. An international consortium (GAMES) was established in order to compare elite endurance athletes and ethnicity- matched controls in a case-control study design. Genome-wide association studies were undertaken on two cohorts of elite endurance athletes and controls (GENATHLETE and Japanese endurance runners), from which a panel of 45 promising markers was identified. These markers were tested for replication in seven additional cohorts of endurance athletes and controls: from Australia, Ethiopia, Japan, Kenya, Poland, Russia and Spain. The study is based on a total of 1520 endurance athletes (835 who took part in endurance events in World Championships and/or Olympic Games) and 2760 controls. We hypothesized that world-class athletes are likely to be characterized by an even higher concentration of endurance performance alleles and we performed separate analyses on this subsample. The meta-analysis of all available studies revealed one statistically significant marker (rs558129 at GALNTL6 locus, p = 0.0002), even after correcting for multiple testing. As shown by the low heterogeneity index (I2 = 0), all eight cohorts showed the same direction of association with rs558129, even though p-values varied across the individual studies. In summary, this study did not identify a panel of genomic variants common to these elite endurance athlete groups. Since GAMES was underpowered to identify alleles with small effect sizes, some of the suggestive leads identified should be explored in expanded comparisons of world-class endurance athletes and sedentary controls and in tightly controlled exercise training studies. Such studies have the potential to illuminate the biology not only of world class endurance performance but also of compromised cardiac functions and cardiometabolic diseases.
| Item Type: | Article |
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| Uncontrolled Keywords: | Science & Technology; Multidisciplinary Sciences; Science & Technology - Other Topics; GENOME-WIDE ASSOCIATION; CELL GENETIC-VARIATION; EXERCISE HEART-RATE; HERITAGE FAMILY; AEROBIC POWER; LINKAGE SCAN; POLYMORPHISM; PERFORMANCE; IDENTIFICATION; GENOTYPE; Humans; N-Acetylgalactosaminyltransferases; Genetic Markers; Maximal Expiratory Flow Rate; Gene Expression; Oxygen Consumption; Physical Endurance; Gene Frequency; Genetic Heterogeneity; Polymorphism, Single Nucleotide; Alleles; Genome, Human; Physical Fitness; Adult; Male; Genome-Wide Association Study; Athletes; Genetic Loci; DNA Copy Number Variations; Sedentary Behavior; Polypeptide N-acetylgalactosaminyltransferase; Adult; Alleles; Athletes; DNA Copy Number Variations; Gene Expression; Gene Frequency; Genetic Heterogeneity; Genetic Loci; Genetic Markers; Genome, Human; Genome-Wide Association Study; Humans; Male; Maximal Expiratory Flow Rate; N-Acetylgalactosaminyltransferases; Oxygen Consumption; Physical Endurance; Physical Fitness; Polymorphism, Single Nucleotide; Sedentary Behavior; Polypeptide N-acetylgalactosaminyltransferase; General Science & Technology |
| Subjects: | Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Public Library of Science (PLoS) |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 29 Apr 2024 15:17 |
| Last Modified: | 29 Apr 2024 15:30 |
| DOI or ID number: | 10.1371/journal.pone.0147330 |
| Editors: | Raleigh, S |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/23060 |
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