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Sports genomics: Current state of knowledge and future directions

Ahmetov, II and Fedotovskaya, ON (2012) Sports genomics: Current state of knowledge and future directions. Cellular and Molecular Exercise Physiology, 1 (1). ISSN 2049-419X

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Athletic performance is a heritable trait influenced by both environmental and genetic factors. Sports genomics is a relatively new scientific discipline focusing on the organization and functioning of the genome of elite athletes. With genotyping becoming widely available, a large number of genetic case-control studies evaluating candidate gene variants have been published with largely unconfirmed associations with elite athlete status. This review summarizes the evidence and mechanistic insights on the associations between DNA polymorphisms and athletic performance. A literature search (period: 1997-2012; number of articles: 133) revealed that at least 79 genetic markers are linked to elite athlete status (59 endurance-related genetic markers and 20 power/strength-related genetic markers). Importantly, we have identified 20 genetic markers (25.3%) that have shown positive associations with athlete status in at least two studies (14 endurance-related genetic markers:. However, sports genomics is still in the discovery phase and abundant replication studies are needed before these largely pioneering findings can be extended to practice in sport. Future research including genome-wide association studies, whole-genome sequencing, epigenetic, transcriptomic and proteomic profiling will allow a better understanding of genetic make-up and molecular physiology of elite athletes.

Item Type: Article
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: EditSharp Scientific Publication Group
SWORD Depositor: A Symplectic
Date Deposited: 30 Apr 2024 10:48
Last Modified: 30 Apr 2024 10:48
DOI or ID number: 10.7457/cmep.v1i1.e1
URI: https://researchonline.ljmu.ac.uk/id/eprint/23069
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