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Sawczuk, M, Timshina, YI, Astratenkova, IV, Maciejewska-Karlowska, A, Leońska-Duniec, A, Ficek, K, Mustafina, LJ, Cięszczyk, P, Klocek, T and Ahmetov, II (2013) The -9/+9 polymorphism of the bradykinin receptor beta 2 Gene and athlete status: A study involving two European cohorts. Human Biology, 85 (5). pp. 741-755. ISSN 0018-7143
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Is the 99 polymorphism of the bradykinin receptor beta 2 (BDKRB2) gene associated with athlete status.pdf - Accepted Version Download (192kB) | Preview |
Abstract
Previous studies concerning the relevance of BDKRB2 gene polymorphisms revealed that the absence (-9 allele) of a nine-base-pair sequence in exon 1 of the BDKRB2 gene is correlated with higher skeletal muscle metabolic efficiency, glucose uptake during exercise, and endurance athletic performance. The aim of the study was to investigate the association between the BDKRB2 -9/+9 polymorphism and elite athletic status in two cohorts of eastern European athletes. We examined the genotype distribution of the BDKRB2 9/+9 polymorphic site in a group of Polish athletes and confirmed the results obtained in a replication study of Russian athletes. Three hundred and two Polish athletes and 684 unrelated sedentary controls, as well as 822 Russian athletes and 507 unrelated sedentary volunteers, were recruited for this study. All samples were genotyped for the -9/+9 polymorphism within exon 1 of the BDKRB2 gene using polymerase chain reaction. Significance was assessed by chi square analysis with Bonferroni's correction for multiple testing. We found no statistical difference in the -9/+9 genotype and allele frequencies in two groups of athletes divided into four subgroups: endurance, sprint-endurance, sprint-strength, and strength athletes, compared with controls. There were no significant differences in allele frequencies (p = 0.477) and genotype distribution (p = 0.278) in the initial and replication studies. Thus, no association was found between the BDKRB2 -9/+9 polymorphism and elite athletic status in two cohorts of eastern European athletes.
| Item Type: | Article |
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| Additional Information: | This is a pre-copyedited version of an article accepted for publication in Human Biology, 85(5), 2013 following peer review. The definitive publisher-authenticated version is available from Wayne State University Press |
| Uncontrolled Keywords: | Science & Technology; Life Sciences & Biomedicine; Anthropology; Biology; Genetics & Heredity; Life Sciences & Biomedicine - Other Topics; BDKRB2; BRADYKININ RECEPTOR BETA2 GENE; POLYMORPHISM; ATHLETIC PERFORMANCE; EUROPEAN COHORTS; POTENTIAL ROLE; NITRIC-OXIDE; MUSCLE; METABOLISM; B2; IDENTIFICATION; KALLIKREIN; EXPRESSION; RISK; Humans; Receptor, Bradykinin B2; Cohort Studies; Polymerase Chain Reaction; Gene Frequency; Genotype; Polymorphism, Genetic; Adult; Female; Male; Young Adult; Athletes; Genetic Association Studies; Adult; Athletes; Cohort Studies; Female; Gene Frequency; Genetic Association Studies; Genotype; Humans; Male; Polymerase Chain Reaction; Polymorphism, Genetic; Receptor, Bradykinin B2; Young Adult; 0604 Genetics; Genetics & Heredity |
| Subjects: | Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Wayne State University Press |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 02 May 2024 12:41 |
| Last Modified: | 02 May 2024 12:41 |
| DOI or ID number: | 10.3378/027.085.0511 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/23070 |
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