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Drozdovska, SB, Dosenko, VE, Ahmetov, II and Ilyin, VN (2013) The association of gene polymorphisms with athlete status in Ukrainians. Biology of Sport, 30 (3). pp. 163-167. ISSN 0860-021X
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Abstract
Athletic performance is a polygenic trait influenced by both environmental and genetic factors. Objective: to investigate individually and in combination the association of common gene polymorphisms with athlete status in Ukrainians. Methods: A total of 210 elite Ukrainian athletes (100 endurance-oriented and 110 power-orientated athletes) and 326 controls were genotyped for ACE I/D, HIF1A Pro582Ser, NOS3-786 T/C, PPARA intron 7 G/C, PPARG Pro12Ala and PPARGC1B Ala203Pro gene polymorphisms, most of which were previously reported to be associated with athlete status or related intermediate phenotypes in different populations. Results: Power-oriented athletes exhibited an increased frequency of the HIF1A Ser (16.1 vs. 9.4%, P = 0.034) and NOS3 T alleles (78.3 vs. 66.2%, P = 0.0019) in comparison with controls. Additionally, we found that the frequency of the PPARG Ala allele was significantly higher in power-oriented athletes compared with the endurance-oriented athletes (24.7 vs. 13.5%; P = 0.0076). Next, we determined the total genotype score (TGS, from the accumulated combination of the three polymorphisms, with a maximum value of 100 for the theoretically optimal polygenic score) in athletes and controls. The mean TGS was significantly higher in power-oriented athletes (39.1 ± 2.3 vs. 32.6 ± 1.5; P = 0.0142) than in controls. Conclusions: We found that the HIF1A Ser, NOS3 T and PPARG Ala alleles were associated with power athlete status in Ukrainians.
| Item Type: | Article |
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| Uncontrolled Keywords: | Science & Technology; Life Sciences & Biomedicine; Sport Sciences; gene polymorphisms; genetic markers; sport selection; athletic performance; MUSCLE GLUCOSE-UPTAKE; BODY-MASS INDEX; EXERCISE; HUMANS; PERFORMANCE; SIMILARITY; LIMITS; Science & Technology; Life Sciences & Biomedicine; Sport Sciences; gene polymorphisms; genetic markers; sport selection; athletic performance; MUSCLE GLUCOSE-UPTAKE; BODY-MASS INDEX; EXERCISE; HUMANS; PERFORMANCE; SIMILARITY; LIMITS; athletic performance; gene polymorphisms; genetic markers; sport selection; 1106 Human Movement and Sports Sciences; Sport Sciences |
| Subjects: | Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Termedia Publishing |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 30 Apr 2024 11:37 |
| Last Modified: | 30 Apr 2024 11:37 |
| DOI or ID number: | 10.5604/20831862.1059168 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/23072 |
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