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The HIF1A gene Pro582Ser polymorphism in Russian strength athletes

Gabbasov, RT, Arkhipova, AA, Borisova, AV, Hakimullina, AM, Kuznetsova, AV, Williams, AG, Day, SH and Ahmetov, II (2013) The HIF1A gene Pro582Ser polymorphism in Russian strength athletes. Journal of Strength and Conditioning Research, 27 (8). pp. 2055-2058. ISSN 1064-8011

The HIF1A gene Pro582Ser polymorphism in Russian strength athletes.pdf - Accepted Version

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Hypoxiainducible factor-1a (encoded by HIF1A gene) controls a number of genes that are implicated in various cellular functions including glycolysis and cell proliferation and differentiation. The rs11549465 C > T polymorphism in the HIF1A gene, which produces the amino acid substitution Pro582Ser, increases protein stability and transcriptional activity and, therefore, improves glucose metabolism. The aim of our study was to investigate the association between the HIF1A Pro582Ser polymorphism and elite strength athlete status. A total of 208 Russian strength athletes (122 weightlifters and 86 wrestlers) of regional or national competitive standard and 1,413 controls were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. We found that the frequency of the HIF1A 582Ser variant was significantly higher in weightlifters (13.1%, p = 0.0031) and wrestlers (15.7%, p = 0.0002) compared with the controls (7.5%). Additionally, the highest (21.1%, p = 0.0052) frequency of the 582Ser variant was found in a group of elite strength athletes. Thus, our study provides evidence for an association between the HIF1A gene Pro582Ser polymorphism and elite strength athlete status. Although more replication studies are needed, the preliminary data suggest an opportunity to use the analysis of HIF1A polymorphism along with other gene variations and standard phenotypic assessment in sports selection.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in The Journal of Strength and Conditioning Research. The published version of record Gabbasov, Rashid T.; Arkhipova, Alina A.; Borisova, Alyona V.; Hakimullina, Albina M.; Kuznetsova, Alexandra V.; Williams, Alun G.; Day, Stephen H.; Ahmetov, Ildus I.. The HIF1A Gene Pro582Ser Polymorphism in Russian Strength Athletes. Journal of Strength and Conditioning Research 27(8):p 2055-2058, August 2013. | DOI: 10.1519/JSC.0b013e31827f06ae is available online at: https://journals.lww.com/nscajscr/fulltext/2013/08000/the_hif1a_gene_pro582ser_polymorphism_in_russian.1.aspx and http://doi.org/10.1519/jsc.0b013e31827f06ae
Uncontrolled Keywords: Science & Technology; Life Sciences & Biomedicine; Sport Sciences; hypoxia; wrestling; weightlifting; anaerobic glycolysis; GROWTH-FACTOR EXPRESSION; INDUCIBLE FACTOR 1-ALPHA; MUSCLE PHENOTYPE; SIZE; Humans; Case-Control Studies; Glycolysis; Genotype; Polymorphism, Single Nucleotide; Weight Lifting; Wrestling; Adult; Russia; Female; Male; Hypoxia-Inducible Factor 1, alpha Subunit; Muscle Strength; Athletic Performance; Adult; Athletic Performance; Case-Control Studies; Female; Genotype; Glycolysis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Muscle Strength; Polymorphism, Single Nucleotide; Russia; Weight Lifting; Wrestling; 1106 Human Movement and Sports Sciences; 1116 Medical Physiology; Sport Sciences
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Lippincott, Williams & Wilkins
SWORD Depositor: A Symplectic
Date Deposited: 01 May 2024 14:32
Last Modified: 01 May 2024 14:45
DOI or ID number: 10.1519/JSC.0b013e31827f06ae
URI: https://researchonline.ljmu.ac.uk/id/eprint/23075
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