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A common polymorphism of the MCT1 gene and athletic performance

Fedotovskaya, ON, Mustafina, LJ, Popov, DV, Vinogradova, OL and Ahmetov, II (2013) A common polymorphism of the MCT1 gene and athletic performance. International Journal of Sports Physiology and Performance, 9 (1). pp. 173-180. ISSN 1555-0265

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Purpose: In red skeletal muscle, monocarboxylate transporter 1 (MCT1) is required for lactate to enter the myocytes for oxidation. The A1470T polymorphism (rs1049434) in the MCT1 gene was shown to be associated with lactate transport rates in human skeletal muscles. The aim of the study was to compare genotype and allele frequencies of the MCT1 gene polymorphism in 323 Russian athletes and 467 nonathletic controls and to investigate the association of the MCT1 gene A1470T polymorphism with maximal oxygen consumption and maximal lactate concentration in rowers (n = 79). Methods: Genotyping for the A1470T MCT1 polymorphism was performed by PCR-RFLP method. Physiological measurements of 79 Russian rowers of national competitive standard were determined during an incremental test to exhaustion on a rowing ergometer. Results: Frequencies of the A allele (71.8% vs 62.5%, P < .0001) and AA genotype (59.8% vs 39.4%, P < .0001) were significantly higher in endurance-oriented athletes (n = 142) than in the control group. Mean blood lactate concentration was higher in male rowers with the T allele (AT+TT 10.26 ± 1.89 mmol/L, AA 8.75 ± 1.69 mmol/L, P = .005). Conclusions: MCT1 gene A1470T polymorphism is associated with endurance athlete status and blood lactate level after intensive exercise.

Item Type: Article
Additional Information: Accepted author manuscript version reprinted, by permission, from International Journal of Sports Physiology and Performance, 2014, 9 (1): 173-180, https://doi.org/10.1123/IJSPP.2013-0026. © Human Kinetics, Inc.
Uncontrolled Keywords: Science & Technology; Life Sciences & Biomedicine; Physiology; Sport Sciences; monocarboxylate transporter; blood lactate level; endurance athlete; WHITE SKELETAL-MUSCLE; MONOCARBOXYLATE TRANSPORTERS; LACTATE TRANSPORT; LACTIC-ACID; EXPRESSION; RESTRICTION; PHYSIOLOGY; EXERCISE; Humans; Lactic Acid; Monocarboxylic Acid Transporters; Symporters; Exercise Test; Case-Control Studies; Polymerase Chain Reaction; Gene Frequency; Genotype; Polymorphism, Genetic; Adult; Female; Male; Athletic Performance; Adult; Athletic Performance; Case-Control Studies; Exercise Test; Female; Gene Frequency; Genotype; Humans; Lactic Acid; Male; Monocarboxylic Acid Transporters; Polymerase Chain Reaction; Polymorphism, Genetic; Symporters; 1106 Human Movement and Sports Sciences; 1116 Medical Physiology; 1701 Psychology; Sport Sciences
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Human Kinetics
SWORD Depositor: A Symplectic
Date Deposited: 02 May 2024 12:21
Last Modified: 02 May 2024 12:21
DOI or ID number: 10.1123/IJSPP.2013-0026
URI: https://researchonline.ljmu.ac.uk/id/eprint/23078
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