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ACTN3 genotype is associated with testosterone levels of athletes

Ahmetov, II, Donnikov, AE and Trofimov, DY (2014) ACTN3 genotype is associated with testosterone levels of athletes. Biology of Sport, 31 (2). pp. 105-108. ISSN 0860-021X

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α-Actinin-3 (ACTN3) has been proposed to regulate skeletal muscle differentiation and hypertrophy through its interaction with the signalling protein calcineurin. Since the inhibition of calcineurin potentiates the production of testosterone, we hypothesized that a-actinin-3 deficiency (predicted from the ACTN3 XX genotype) may influence serum levels of testosterone of athletes. Objective: To investigate the association of ACTN3 gene R577X polymorphism with resting testosterone levels in athletes. Methods: A total of 209 elite Russian athletes from different sports (119 males, 90 females) were genotyped for ACTN3 gene R577X polymorphism by real-time PCR. Resting testosterone was examined in serum of athletes using enzyme immunoassay. Results: The mean testosterone levels were significantly higher in both males and females with the ACTN3 R allele than in XX homozygotes (males: RR: 24.9 (5.7), RX: 21.8 (5.5), XX: 18.6 (4.9) ng · mL-1, P = 0.0071; females: RR: 1.43 (0.6), RX: 1.21 (0.71), XX: 0.79 (0.66) ng · mL -1, P = 0.0167). Conclusions: We found that the ACTN3 R allele was associated with high levels of testosterone in athletes, and this may explain, in part, the association between the ACTN3 RR genotype, skeletal muscle hypertrophy and power athlete status.

Item Type: Article
Uncontrolled Keywords: Science & Technology; Life Sciences & Biomedicine; Sport Sciences; ACTN3; gene polymorphism; testosterone; calcineurin; muscle hypertrophy; FIBER-TYPE COMPOSITION; R577X POLYMORPHISM; SKELETAL-MUSCLE; ALPHA-ACTININ-3 DEFICIENCY; PERFORMANCE; STRENGTH; GENE; PHENOTYPES; WOMEN; ACE; ACTN3; calcineurin; gene polymorphism; muscle hypertrophy; testosterone; 1106 Human Movement and Sports Sciences; Sport Sciences
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Termedia Publishing
SWORD Depositor: A Symplectic
Date Deposited: 30 Apr 2024 10:34
Last Modified: 30 Apr 2024 10:34
DOI or ID number: 10.5604/20831862.1096046
URI: https://researchonline.ljmu.ac.uk/id/eprint/23079
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