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Sathiyalingam, S and Roesner, S (2022) Synthesis of α- and β-Carbolines by a Metalation/Negishi Cross- Coupling/SNAr Reaction Sequence. Advanced Synthesis & Catalysis, 364 (10). pp. 1769-1774. ISSN 1615-4150
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Synthesis of α and β Carbolines by a Metalation Negishi CrossCoupling SNAr Reaction Sequence.pdf - Published Version Available under License Creative Commons Attribution Non-commercial. Download (4MB) | Preview |
Publisher URL: http://doi.org/10.1002/adsc.202200127
Abstract
A methodology for the synthesis of α- and β-carbolines from fluoropyridines and 2-haloanilines is reported. This procedure consists of a four-step directed ortho-lithiation, zincation, Negishi cross-coupling, and intramolecular nucleophilic aromatic substitution, providing access to a diverse set of functionalized carbolines. While the procedure is applicable to batch conditions, the generation of arylzinc intermediates in continuous flow has been demonstrated.
| Item Type: | Article |
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| Uncontrolled Keywords: | 0302 Inorganic Chemistry; 0305 Organic Chemistry; 0904 Chemical Engineering; Organic Chemistry |
| Subjects: | Q Science > QB Astronomy Q Science > QC Physics |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Wiley |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 23 Apr 2024 10:51 |
| Last Modified: | 23 Apr 2024 13:07 |
| DOI or ID number: | 10.1002/adsc.202200127 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/23113 |
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