Nahar, L, Alsheikh, W, Ritchie, KJ and Sarker, SD (2024) Naturally occurring eugenin: Biosynthesis, distribution, bioactivity, and therapeutic potential. Phytochemistry Letters, 61. pp. 191-197. ISSN 1874-3900

Text Naturally occurring eugenin Biosynthesis distribution bioactivity and therapeutic potential.pdf - Accepted Version Restricted to Repository staff only until 9 May 2025. Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (493kB)

Abstract

Introduction: Eugenin (5-hydroxy-7-methoxy-2-methyl-4H-chromen-4-one) is a bioactive phytoalexin mainly found as a bitter component in carrots (Daucus carota L.; Apiaceae) and cloves [Syzygium aromaticum (L.) Merr. & L. M. Perry; Myrtaceae]. Materials and methods: An extensive literature search was performed involving various established databases like Web of Science, PubMed, Science Direct, Dictionary of Natural Products and Google Scholar, using the keyword ‘eugenin’. The literature reports that describe various aspects of naturally occurring eugenin, e.g., isolation, structure elucidation, biosynthesis, bioactivity studies and therapeutic potential, have been included in this review, while the papers that present total synthesis or structural modifications of eugenin have been excluded. Results: Eugenin, biosynthesized from the acetate-malonate pathway, has been reported from at least 22 plant species from 13 families. It has also been found in two fungal species, Aschersonia confluens and Chaetomium minutum. Dacaus carota and Syzygium aromaticum are two major sources of this chromone. Antimalarial, antimicrobial, antioxidant, antiplatelet aggregation, antiviral, cytotoxic, immunosuppressive/immunomodulatory, osteogenesis-inducing, pyrolyl endopeptidase (PEP)-inhibitory and blue-green algae growth inhibitory activities of eugenin have been reported in the literature. Among these bioactivities, antioxidant, antiplatelet aggregation, immunosuppressive/immunomodulatory activities of eugenin and its in silico prediction of antiviral property against severe-acute-respiratory-syndrome-related coronavirus-2 (SARS-CoV-2) activity may have some therapeutic potential. Conclusion: The distribution of eugenin is rather limited to a few plant species and only a couple of fungal species. Based on the reported bioactivities, it could be concluded that this chromone might have some potential as a template for new drug development.

Item Type:	Article
Subjects:	Q Science > QH Natural history > QH301 Biology R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy & Biomolecular Sciences
Publisher:	Elsevier
SWORD Depositor:	A Symplectic
Date Deposited:	02 May 2024 08:55
Last Modified:	16 May 2024 10:22
DOI or ID number:	10.1016/j.phytol.2024.04.017
URI:	https://researchonline.ljmu.ac.uk/id/eprint/23158

View Item