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Rahimi, MR 
ORCID: 0000-0002-4302-1472, Semenova, EA ORCID: 0000-0003-1248-2855, John, G, Fallah, F, Larin, AK ORCID: 0000-0002-9429-792X, Generozov, EV ORCID: 0000-0002-6314-4883 and Ahmetov, II ORCID: 0000-0002-6335-4020
(2024)
Effect of ADORA2A Gene Polymorphism and Acute Caffeine Supplementation on Hormonal Response to Resistance Exercise: A Double-Blind, Crossover, Placebo-Controlled Study.
Nutrients, 16 (12).
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Abstract
Previous studies have reported that TT genotype carriers of the adenosine A2a receptor (ADORA2A) gene rs5751876 polymorphism have better ergogenic and anti-inflammatory responses to caffeine intake compared to C allele carriers. The aim of the present study was twofold: (1) to investigate the association of the ADORA2A rs5751876 polymorphism with acute caffeine supplementation on hormonal (growth hormone and testosterone) response to resistance exercise (RE); (2) to examine the relationship between the rs5751876 polymorphism and the resting levels of growth hormone and testosterone in athletes who are light caffeine consumers. A double-blind, crossover, placebo-controlled study involving 30 resistance-trained men (age 21.7 ± 4.1) was conducted to assess the impact of caffeine supplementation on serum growth hormone (GH) and testosterone (TS) levels before, immediately after, and 15 min post-RE. One hour before engaging in resistance exercise, subjects were randomly administered 6 mg of caffeine per kg of body mass or a placebo (maltodextrin). After a 7-day washout period, the same protocol was repeated. Resting testosterone and growth hormone levels were examined in the sera of 94 elite athletes (31 females, age 21.4 ± 2.8; 63 males, age 22.9 ± 3.8). Caffeine consumption led to significantly greater increases in GH and TS in men with the TT genotype compared to C allele carriers. Furthermore, in the group of athletes, carriers of the TT genotype had significantly higher testosterone (p = 0.0125) and growth hormone (p = 0.0365) levels compared to C allele carriers. In conclusion, the ADORA2A gene rs5751876 polymorphism may modify the effect of caffeine intake on the hormonal response to exercise.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 0908 Food Sciences; 1111 Nutrition and Dietetics |
| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport and Exercise Sciences |
| Publisher: | MDPI |
| Date of acceptance: | 6 June 2024 |
| Date of first compliant Open Access: | 14 June 2024 |
| Date Deposited: | 14 Jun 2024 09:56 |
| Last Modified: | 04 Jul 2025 11:30 |
| DOI or ID number: | 10.3390/nu16121803 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/23491 |
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