Shahbaz, SK, Koushki, K, Izadi, O, Penson, PE, Sukhorukov, VN, Kesharwani, P and Sahebkar, A (2024) Advancements in Curcumin-Loaded PLGA Nanoparticle Delivery Systems: Progressive Strategies in Cancer Therapy. Journal of Drug Targeting. pp. 1-53. ISSN 1061-186X

Text Revised Manuscript (curcumin PLGA) R2.pdf - Accepted Version Restricted to Repository staff only until 12 August 2025. Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (1MB)

Abstract

Cancer is a leading cause of death worldwide, and imposes a substantial socioeconomic burden with little impact especially on aggressive types of cancer. Conventional therapies have many serious side effects including generalized systemic toxicity which limits their long-term use. Tumor resistance and recurrence is another main problem associated with conventional therapy. Purified or extracted natural products have been investigated as cost-effective cancer chemoprotective agents with the potential to reverse or delaying carcinogenesis. Curcumin (CUR) as a natural polyphenolic component, exhibits many pharmacological activities such as anti-cancer, anti-inflammatory, anti-microbial, activity against neurodegenerative diseases including Alzheimer, antidiabetic activities (type II diabetes), anticoagulant properties, wound healing effects in both preclinical and clinical studies. Despite these effective protective properties, CUR has several limitations, including poor aqueous solubility, low bioavailability, chemical instability, rapid metabolism and a short half-life time. To overcome the pharmaceutical problems associated with free CUR, novel nanomedicine strategies (including polymeric nanoparticles (NPs) such as poly (lactic-co-glycolic acid) (PLGA) NPs) have been developed. These formulations have the potential to improve the therapeutic efficacy of curcuminoids. In this review, we comprehensively summarize and discuss recent in vitro and in vivo studies to explore the pharmaceutical significance and clinical benefits of PLGA-NPs delivery system to improve the efficacy of CUR in the treatment of cancer.

Item Type:	Article
Additional Information:	This is an Accepted Manuscript version of the following article, accepted for publication in Journal of Drug Targeting. Keshavarz Shahbaz, S., Koushki, K., Izadi, O., Penson, P. E., Sukhorukov, V. N., Kesharwani, P., & Sahebkar, A. (2024). Advancements in curcumin-loaded PLGA nanoparticle delivery systems: progressive strategies in cancer therapy. Journal of Drug Targeting, 1–26. https://doi.org/10.1080/1061186X.2024.2389892 It is deposited under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (Deed - Attribution-NonCommercial-NoDerivatives 4.0 International - Creative Commons ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
Uncontrolled Keywords:	1115 Pharmacology and Pharmaceutical Sciences; Pharmacology & Pharmacy
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy & Biomolecular Sciences
Publisher:	Taylor and Francis Group
SWORD Depositor:	A Symplectic
Date Deposited:	13 Aug 2024 10:07
Last Modified:	13 Aug 2024 10:07
DOI or ID number:	10.1080/1061186x.2024.2389892
URI:	https://researchonline.ljmu.ac.uk/id/eprint/23921

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