Gomez-Escolar, A, Folch-Sanchez, D, Stefaniuk, J, Swithenbank, Z, Nisa, A, Braddick, F, Idrees Chaudhary, N, van der Meer, PB and Batalla, A (2024) Current Perspectives on the Clinical Research and Medicalization of Psychedelic Drugs for Addiction Treatments: Safety, Efficacy, Limitations and Challenges. CNS Drugs. ISSN 1172-7047

Text Current Perspectives on the Clinical Research and Medicalization of Psychedelic Drugs for Addiction Treatments Safety, Efficacy, Limitations and Challenges.pdf - Accepted Version Restricted to Repository staff only until 20 July 2025. Download (533kB)

Abstract

Mental health disorders and substance use disorders (SUDs) in particular, contribute greatly to the global burden of disease. Psychedelics, including entactogens and dissociative substances, are currently being explored for the treatment of SUDs, yet with less empirical clinical evidence than for other mental health disorders, such as depression or post-traumatic stress disorder (PTSD). In this narrative review, we discuss the current clinical research evidence, therapeutic potential and safety of psilocybin, lysergic acid diethylamide (LSD), ketamine, 3,4-methylenedioxymethamphetamine (MDMA) and ibogaine, particularly in the context of the SUD treatment. Our aim was to provide a balanced overview of the current research and findings on potential benefits and harms of psychedelics in clinical settings for SUD treatment. We highlight the need for more clinical research in this particular treatment area and point out some limitations and challenges to be addressed in future research.

Item Type:	Article
Additional Information:	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://doi.org/10.1007/s40263-024-01101-3
Uncontrolled Keywords:	1103 Clinical Sciences; 1109 Neurosciences; 1115 Pharmacology and Pharmaceutical Sciences; Psychiatry
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RS Pharmacy and materia medica R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Nursing & Allied Health Public Health Institute
Publisher:	Springer
SWORD Depositor:	A Symplectic
Date Deposited:	03 Sep 2024 08:49
Last Modified:	03 Sep 2024 08:49
DOI or ID number:	10.1007/s40263-024-01101-3
URI:	https://researchonline.ljmu.ac.uk/id/eprint/24067

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