Denby, CE, Chatterjee, K, Pullicino, R, Lane, S, Radon, MR and Das, KV (2020) Is four-dimensional CT angiography as effective as digital subtraction angiography in the detection of the underlying causes of intracerebral haemorrhage: a systematic review. Neuroradiology, 62 (3). pp. 273-281. ISSN 0028-3940

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Abstract

Purpose: To determine whether the sensitivity and specificity of four-dimensional CTA (4D-CTA) are equivalent to digital subtraction angiography (DSA) in the detection of underlying vascular abnormalities in patients with intracerebral haemorrhage (ICH). Methods: A systematic review of studies comparing 4D-CTA with DSA in the detection of the underlying structural causes of ICH was performed on the literature published between 1998 and 2019. Results: We identified a total of 237 articles from PubMed, SCOPUS and Web of Science using the following Medical Subject Headings (MeSH) terms: primary intracerebral haemorrhage, 4D-CTA, DSA, cerebral haemorrhage, angiography, digital subtraction, arteriovenous malformations, 4D, CTA, dynamic-CTA and time-resolved CTA. Following the removal of duplicate publications and articles failing to meet our inclusion criteria, there were four articles potentially viable for analysis. Therefore, there were not sufficient studies to provide a statistically meaningful meta-analysis. Conclusion: The review of current literature has demonstrated that there are few published studies comparing 4D-CTA with DSA in spontaneous ICH, with only four suitable studies identified for potential analysis. However, due to the restricted number of patients and high sensitivity and specificity of 3 studies (100%), performing a meta-analysis was not meaningful. Qualitative analysis of the data concluded that 4D-CTA has the diagnostic potential to replace invasive DSA in certain cases with vascular abnormalities. However, further research studies directly comparing 4D-CTA with DSA using larger prospective patient cohorts are required to strengthen the evidence base.

Item Type:	Article
Uncontrolled Keywords:	Four-dimensional CTA (4D-CTA); Digital subtraction angiography (DSA); Intracerebral haemorrhage (ICH); Haemorrhagic stroke; Vascular abnormalities; Systematic review; Humans; Intracranial Arteriovenous Malformations; Cerebral Hemorrhage; Angiography, Digital Subtraction; Cerebral Angiography; Sensitivity and Specificity; Four-Dimensional Computed Tomography; Digital subtraction angiography (DSA); Four-dimensional CTA (4D-CTA); Haemorrhagic stroke; Intracerebral haemorrhage (ICH); Systematic review; Vascular abnormalities; Angiography, Digital Subtraction; Cerebral Angiography; Cerebral Hemorrhage; Four-Dimensional Computed Tomography; Humans; Intracranial Arteriovenous Malformations; Sensitivity and Specificity; 1103 Clinical Sciences; 1109 Neurosciences; Nuclear Medicine & Medical Imaging
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Nursing and Advanced Practice
Publisher:	Springer
SWORD Depositor:	A Symplectic
Date Deposited:	23 Oct 2024 10:30
Last Modified:	23 Oct 2024 10:30
DOI or ID number:	10.1007/s00234-019-02349-z
URI:	https://researchonline.ljmu.ac.uk/id/eprint/24569

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