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Famurewa, AC, Prabhune, NM and Prabhu, S (2024) Natural product mitigation of ferroptosis in platinum-based chemotherapy toxicity: targeting the underpinning oxidative signaling pathways. Journal of Pharmacy and Pharmacology. pp. 1-17. ISSN 0022-3573
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Natural product mitigation of ferroptosis in platinumbased chemotherapy toxicity targeting the underpinning oxidative signaling pathways.pdf - Published Version Available under License Creative Commons Attribution Non-commercial. Download (1MB) | Preview |
Abstract
Objectives: Platinum-based anticancer chemotherapy (PAC) represents a cornerstone in cancer treatment, retaining its status as the gold standard therapy. However, PAC’s efficacy is countered by significant toxicities, such as nephrotoxicity, ototoxicity, and neurotoxicity. Recent studies have linked these toxicities to ferroptosis, characterized by iron accumulation, reactive oxygen species generation, and lipid peroxidation. This review explores the mechanisms underlying PAC-induced toxicities, focusing on the involvement of ferroptosis with three major PAC drugs—cisplatin, carboplatin, and oxaliplatin. Further, we provide a comprehensive analysis of the natural product mitigation of PAC-induced ferroptotic toxicity. Key findings: The mechanistic role of ferroptosis in cisplatin- and oxaliplatin-induced toxicities has been investigated, while studies on carboplatin-induced ferroptotic toxicities are lacking. Natural compounds targeting molecular pathways of ferroptosis have been explored to mitigate PAC-induced ferroptotic toxicity. Conclusion: While ferroptosis in cisplatin- and oxaliplatin-induced toxicities has been investigated, there remains a notable dearth of studies examining its involvement in carboplatin-induced toxicities. Hence, further exploration is warranted to define the role of ferroptosis in carboplatininduced toxicities, and its further mitigation. Moreover, in-depth mechanistic evaluation is necessary to establish natural products evaluated against PAC-induced ferroptosis, as PAC adjuvants.
| Item Type: | Article |
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| Uncontrolled Keywords: | platinum-based anticancer drugs; cisplatin toxicity; ferroptosis; natural ferroptosis inhibitors; cisplatin toxicity; ferroptosis; natural ferroptosis inhibitors; platinum-based anticancer drugs; Cancer; Digestive Diseases; Cancer; 1115 Pharmacology and Pharmaceutical Sciences; 1116 Medical Physiology; Pharmacology & Pharmacy |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy and Biomolecular Sciences |
| Publisher: | Oxford University Press |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 29 Nov 2024 13:50 |
| Last Modified: | 29 Nov 2024 14:00 |
| DOI or ID number: | 10.1093/jpp/rgae132 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/24946 |
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