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Alturki, HA, Elsawy, HA and Famurewa, AC (2022) Silymarin abrogates acrylamide-induced oxidative stress-mediated testicular toxicity via modulation of antioxidant mechanism, DNA damage, endocrine deficit and sperm quality in rats. Andrologia, 54 (9). e14491. ISSN 0303-4569
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Silymarin abrogates acrylamideinduced oxidative stress mediated testicular toxicity.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Acrylamide (ACR) is a toxic chemical formed in foods processed at high temperature; it is a food-borne toxicant with increasing public health attention due to its carcinogenic, neurotoxic and reproductive toxicities. However, till date, it is unknown whether silymarin (SIL) could attenuate ACR testicular toxicity. Therefore, the present study investigated the effect of SIL on ACR testiculotoxicity in rats. Rats were randomly divided and administered respective agents in Control group, ACR group, SIL group and ACR + SIL group for consecutive 14 days. Rat exposure to ACR resulted in significant reduction in the level of serum testosterone, whereas FSH and LH levels prominently increased compared to control. Acrylamide induced marked decreases in sperm count and sperm motility followed by a considerable increase in sperm abnormality percentage in the ACR-exposed rats in comparison to control. The testicular activities of glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) were significantly diminished, whereas malondialdehyde (MDA) level considerably increased. Additionally, ACR induced marked DNA fragmentation and histopathological lesions compared to control. Interestingly, the co-treatment of SIL with ACR attenuated the altered reproductive indices and restored antioxidant balance and DNA integrity. Overall, SIL prevents ACR-induced testicular reproductive deficits via modulation of antioxidant mechanism in rats.
| Item Type: | Article |
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| Uncontrolled Keywords: | Testis; Spermatozoa; Semen; Animals; Rats; DNA Damage; Acrylamide; Silymarin; Superoxide Dismutase; Antioxidants; Sperm Motility; Oxidative Stress; Male; acrylamide; oxidative stress; silymarin; sperm cell; testis; Acrylamide; Animals; Antioxidants; DNA Damage; Male; Oxidative Stress; Rats; Semen; Silymarin; Sperm Motility; Spermatozoa; Superoxide Dismutase; Testis; Prevention; Contraception/Reproduction; 3 Good Health and Well Being; Acrylamide; Animals; Antioxidants; DNA Damage; Male; Oxidative Stress; Rats; Semen; Silymarin; Sperm Motility; Spermatozoa; Superoxide Dismutase; Testis; 1103 Clinical Sciences; 1114 Paediatrics and Reproductive Medicine; Obstetrics & Reproductive Medicine |
| Subjects: | Q Science > QH Natural history > QH301 Biology R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy and Biomolecular Sciences |
| Publisher: | Wiley |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 03 Dec 2024 16:47 |
| Last Modified: | 03 Dec 2024 17:00 |
| DOI or ID number: | 10.1111/and.14491 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/25000 |
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