Nahar, L, Hagiya, H, Gotoh, K, Asaduzzaman, M and Otsuka, F (2024) New Delhi Metallo-Beta-Lactamase Inhibitors: A Systematic Scoping Review. Journal of Clinical Medicine, 13 (14). p. 4199. ISSN 2077-0383

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Abstract

Background/Objectives: Among various carbapenemases, New Delhi metallo-beta-lactamases (NDMs) are recognized as the most powerful type capable of hydrolyzing all beta-lactam antibiotics, often conferring multi-drug resistance to the microorganism. The objective of this review is to synthesize current scientific data on NDM inhibitors to facilitate the development of future therapeutics for challenging-to-treat pathogens. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews, we conducted a MEDLINE search for articles with relevant keywords from the beginning of 2009 to December 2022. We employed various generic terms to encompass all the literature ever published on potential NDM inhibitors. Results: Out of the 1760 articles identified through the database search, 91 met the eligibility criteria and were included in our analysis. The fractional inhibitory concentration index was assessed using the checkerboard assay for 47 compounds in 37 articles, which included 8 compounds already approved by the Food and Drug Administration (FDA) of the United States. Time-killing curve assays (14 studies, 25%), kinetic assays (15 studies, 40.5%), molecular investigations (25 studies, 67.6%), in vivo studies (14 studies, 37.8%), and toxicity assays (13 studies, 35.1%) were also conducted to strengthen the laboratory-level evidence of the potential inhibitors. None of them appeared to have been applied to human infections. Conclusions: Ongoing research efforts have identified several potential NDM inhibitors; however, there are currently no clinically applicable drugs. To address this, we must foster interdisciplinary and multifaceted collaborations by broadening our own horizons.

Item Type:	Article
Uncontrolled Keywords:	antimicrobial resistance; carbapenem-resistant Enterobacterales; carbapenemase-producing Enterobacterales; combination; metallo-beta-lactamase; synergy; Antimicrobial Resistance; Infectious Diseases; 3 Good Health and Well Being; 1103 Clinical Sciences
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	MDPI AG
SWORD Depositor:	A Symplectic
Date Deposited:	19 Dec 2024 13:37
Last Modified:	19 Dec 2024 13:45
DOI or ID number:	10.3390/jcm13144199
URI:	https://researchonline.ljmu.ac.uk/id/eprint/25132

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