Tools
Tools
Edwards, M, Graziadio, S, Shore, J, Schmitz, ND, Galvain, T, Danker, WA, Kocaman, M, Pournaras, DJ, Bowley, DM and Hardy, KJ (2023) Plus Sutures for preventing surgical site infection: a systematic review of clinical outcomes with economic and environmental models. BMC Surgery, 23 (1). ISSN 1471-2482
|
Text
Plus Sutures for preventing surgical site infection a systematic review of clinical outcomes with economic and environmental models.pdf - Published Version Available under License Creative Commons Attribution Non-commercial. Download (2MB) | Preview |
Abstract
Background: Surgical site infections (SSIs) represent ~ 20% of all hospital-acquired infections in surgical patients and are associated with prolonged hospital stay, admission to intensive care, and mortality. We conducted a systematic review with economic and environmental models to assess whether triclosan-coated sutures (Plus Sutures) provide benefits over non-coated sutures in the reduction of SSI risk. Methods: Searches were conducted in fifteen databases. A total of 1,991 records were retrieved. Following deduplication and screening by two independent reviewers, 31 randomized controlled trials in adults and children were included in the review. Similarity of the studies was assessed by narrative review and confirmed by quantitative assessment. A fixed effects meta-analysis of SSI incidence model including all groups of patients estimated a risk ratio of 0.71 (95% confidence interval: 0.64 to 0.79) indicating those in the Plus Sutures group had a 29% reduction in the risk of developing an SSI compared with those in the control group (p < 0.001). Safety outcomes were analysed qualitatively. Results: The economic model estimated the use of Plus Sutures to result in average cost savings of £13.63 per patient. Plus Sutures remained cost-saving in all subgroup analyses with cost-savings ranging between £11 (clean wounds) and £140 (non-clean wounds). The environmental impact of SSI is substantial, and the model suggests that the introduction of Plus Sutures could result in potential environmental benefits. Conclusions: The evidence suggests that Plus Sutures are associated with a reduced incidence of SSI across all surgery types alongside cost savings when compared with standard sutures.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans; Surgical Wound Infection; Triclosan; Anti-Infective Agents, Local; Length of Stay; Sutures; Adult; Child; Randomized Controlled Trials as Topic; Antibiotic coating; Infection; Meta-analysis; SSI; Surgery; Sutures; Systematic review; Triclosan; Adult; Child; Humans; Anti-Infective Agents, Local; Surgical Wound Infection; Triclosan; Sutures; Length of Stay; Randomized Controlled Trials as Topic; Patient Safety; Infection; Adult; Child; Humans; Anti-Infective Agents, Local; Surgical Wound Infection; Triclosan; Sutures; Length of Stay; Randomized Controlled Trials as Topic; 1103 Clinical Sciences; Surgery |
| Subjects: | R Medicine > RD Surgery R Medicine > RT Nursing |
| Divisions: | Computer Science and Mathematics |
| Publisher: | Springer Science and Business Media LLC |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 19 Dec 2024 14:12 |
| Last Modified: | 19 Dec 2024 14:15 |
| DOI or ID number: | 10.1186/s12893-023-02187-0 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/25138 |
 |
View Item |