Tools
Tools
Quickfall, M, Green, S, Hesketh, K, Veldhuijzen Van Zanten, J, Cocks, M, Reynolds, J and Wadley, AJ (2025) EXamining the feasibility of exerCisE to manage symptoms of Lupus (EXCEL): A protocol for a randomised controlled pilot study. Lupus Science and Medicine, 12 (1). ISSN 2053-8790
|
Text
EXamining the feasibility of exerCisE to manage symptoms of Lupus EXCEL a protocol for a randomised controlled pilot study.pdf - Published Version Available under License Creative Commons Attribution Non-commercial. Download (492kB) | Preview |
Abstract
Introduction SLE is a chronic autoimmune disease that results in sustained hyperactivation of innate and adaptive immune cells and widespread inflammatory damage. Regular exercise reduces SLE symptoms including fatigue and joint pain and improves patient quality of life. However, most individuals with SLE are not sufficiently active to achieve these benefits, and guidance on the optimal approach to exercise is limited. EXCEL will examine the feasibility of conducting a large-scale randomised controlled trial comparing the effects of a remotely monitored, home-based, exercise programme with standard of care for individuals with SLE. Methods and analysis 30 females with SLE will be recruited, and those randomised into Exercise (SLE-Ex) will codesign a progressive training plan with support from the research team. The aim of each 12-week plan will be to complete 150 min of moderate (60-70% heart rate max, HR max) or 90 min of vigorous exercise (>70% HR max) per week. SLE-Ex will be encouraged to exercise independently (without support) from weeks 13-18. Participants with SLE that are randomised into Control (SLE-Con) will maintain habitual activity without support for 18 weeks. Measures of feasibility and acceptability will be reported, and peripheral blood will be collected at weeks 0, 12 and 18 to explore whether the frequency, phenotype and metabolic profile of lymphocyte subsets has changed. Biomarkers of SLE activity, and self-reported measures of fatigue, sleep quality and health-related quality of life will also be monitored at these timepoints. Blood and self-reported measures will be compared with a healthy control (HC) group (n=15, age and body mass index matched) at baseline only. Ethics and dissemination A favourable ethical opinion was given by South East Scotland Research Ethics Committee (22/SS/0082). Findings will be disseminated at conferences and published in peer-reviewed journals.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans; Lupus Erythematosus, Systemic; Fatigue; Exercise; Exercise Therapy; Feasibility Studies; Pilot Projects; Quality of Life; Adult; Female; Randomized Controlled Trials as Topic; Autoimmunity; Exercise Therapy; Systemic Lupus Erythematosus; Humans; Lupus Erythematosus, Systemic; Pilot Projects; Female; Feasibility Studies; Exercise Therapy; Quality of Life; Adult; Fatigue; Exercise; Randomized Controlled Trials as Topic; 32 Biomedical and Clinical Sciences; 3202 Clinical Sciences; Autoimmune Disease; Clinical Research; Health Disparities; Lupus; Behavioral and Social Science; Women's Health; Prevention; Physical Activity; Clinical Trials and Supportive Activities; Minority Health; 6.7 Physical; Inflammatory and immune system; 3 Good Health and Well Being; Humans; Lupus Erythematosus, Systemic; Pilot Projects; Female; Feasibility Studies; Exercise Therapy; Quality of Life; Adult; Fatigue; Exercise; Randomized Controlled Trials as Topic; 3202 Clinical sciences; 3204 Immunology |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport and Exercise Sciences |
| Publisher: | BMJ |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 07 Feb 2025 17:27 |
| Last Modified: | 07 Feb 2025 17:30 |
| DOI or ID number: | 10.1136/lupus-2024-001382 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/25573 |
 |
View Item |