Tsoneva, DK, Napoli, A, Teneva, M, Mazza, T and Vinciguerra, M (2025) Downregulation of Aging-Associated Gene SUCLG1 Marks the Aggressiveness of Liver Disease. Cancers, 17 (3). p. 339. ISSN 2072-6694

Preview

Text Downregulation of Aging Associated Gene SUCLG1 Marks the Aggressiveness of Liver Disease.pdf - Published Version Available under License Creative Commons Attribution. Download (2MB) | Preview

Abstract

INTRODUCTION: The most common liver disease is nonalcoholic fatty liver disease, characterized by an intrahepatic accumulation of lipids that most often accompanies obesity. Fatty liver can evolve, in the presence of oxidative stress and inflammation, into disabling and deadly liver diseases such as cirrhosis, hepatocellular carcinoma (HCC), and cholangiocarcinoma (CC). Old age seems to favor HCC and CC, in agreement with the inflammaging theory, according to which aging accrues inflammation. Cancer, in general, is an age-related disease, as incidence and mortality for most types of cancer increase with age. However, how molecular drivers in tumors differ or are mutated more frequently among patients of different ages remains scarcely investigated. A recent integrative analysis of the age-associated multi-omic landscape across cancers and healthy tissues demonstrated that age-related gene expression changes are linked to numerous biological processes. HCC and CC have among the lowest five-year survival estimates due to their aggressive progression. MATERIALS AND METHODS: In this study, we extracted top gene candidates from the above-mentioned pan-analyses (i.e., B2M, C1qA, SUCLG1) and tested by qPCR their expression and their correlation with disease progression in 48 tissue samples covering liver disease stages (fatty liver, hepatitis, cirrhosis, HCC and CC) and normal tissues. RESULTS: Here, we report a significant downregulation in the expression of the age-associated gene SUCLG1 during the progression of liver disease toward HCC and CC, which also associates with poor patient survival. CONCLUSION: SUCGL1, a mitochondrial enzyme gene that catalyzes the conversion of succinyl CoA to succinate, might be therapeutically targeted for the development and progression of age-associated liver cancers with low survival rates.

Item Type:	Article
Uncontrolled Keywords:	aging; cancer; gene expression; liver disease; 32 Biomedical and Clinical Sciences; 3211 Oncology and Carcinogenesis; Cancer; Genetics; Nutrition; Aging; Digestive Diseases; Rare Diseases; Liver Disease; Liver Cancer; Chronic Liver Disease and Cirrhosis; Hepatitis; 2.1 Biological and endogenous factors; Cancer; 3 Good Health and Well Being; 1112 Oncology and Carcinogenesis; 3211 Oncology and carcinogenesis
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	MDPI
SWORD Depositor:	A Symplectic
Date Deposited:	20 Feb 2025 13:47
Last Modified:	20 Feb 2025 14:00
DOI or ID number:	10.3390/cancers17030339
URI:	https://researchonline.ljmu.ac.uk/id/eprint/25689

View Item