Blodgett, JM, Ahmadi, MN, Atkin, AJ, Chastin, S, Chan, H-W, Suorsa, K, Bakker, EA, Hettiarcachchi, P, Johansson, PJ, Sherar, LB, Rangul, V, Pulsford, RM, Mishra, G, Eijsvogels, TMH, Stenholm, S, Hughes, AD, Teixeira-Pinto, AM, Ekelund, U, Lee, I-M, Holtermann, A et al, Koster, A, Stamatakis, E, Hamer, M, Thijssen, DHJ and ProPASS Collaboration, (2023) Device-measured physical activity and cardiometabolic health: the Prospective Physical Activity, Sitting, and Sleep (ProPASS) consortium. European Heart Journal, 45 (6). pp. 458-471. ISSN 0195-668X

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Abstract

Background and Aims Physical inactivity, sedentary behaviour (SB), and inadequate sleep are key behavioural risk factors of cardiometabolic diseases. Each behaviour is mainly considered in isolation, despite clear behavioural and biological interdependencies. The aim of this study was to investigate associations of five-part movement compositions with adiposity and cardiometabolic biomarkers. Methods Cross-sectional data from six studies (n = 15 253 participants; five countries) from the Prospective Physical Activity, Sitting and Sleep consortium were analysed. Device-measured time spent in sleep, SB, standing, light-intensity physical activity (LIPA), and moderate-vigorous physical activity (MVPA) made up the composition. Outcomes included body mass index (BMI), waist circumference, HDL cholesterol, total:HDL cholesterol ratio, triglycerides, and glycated haemoglobin (HbA1c). Compositional linear regression examined associations between compositions and outcomes, including modelling time reallocation between behaviours. Results The average daily composition of the sample (age: 53.7 ± 9.7 years; 54.7% female) was 7.7 h sleeping, 10.4 h sedentary, 3.1 h standing, 1.5 h LIPA, and 1.3 h MVPA. A greater MVPA proportion and smaller SB proportion were associated with better outcomes. Reallocating time from SB, standing, LIPA, or sleep into MVPA resulted in better scores across all outcomes. For example, replacing 30 min of SB, sleep, standing, or LIPA with MVPA was associated with −0.63 (95% confidence interval −0.48, −0.79), −0.43 (−0.25, −0.59), −0.40 (−0.25, −0.56), and −0.15 (0.05, −0.34) kg/m2 lower BMI, respectively. Greater relative standing time was beneficial, whereas sleep had a detrimental association when replacing LIPA/MVPA and positive association when replacing SB. The minimal displacement of any behaviour into MVPA for improved cardiometabolic health ranged from 3.8 (HbA1c) to 12.7 (triglycerides) min/day. Conclusions Compositional data analyses revealed a distinct hierarchy of behaviours. Moderate-vigorous physical activity demonstrated the strongest, most time-efficient protective associations with cardiometabolic outcomes. Theoretical benefits from reallocating SB into sleep, standing, or LIPA required substantial changes in daily activity.

Item Type:	Article
Uncontrolled Keywords:	ProPASS Collaboration ; Humans; Cardiovascular Diseases; Triglycerides; Exercise; Prospective Studies; Cross-Sectional Studies; Sleep; Adult; Middle Aged; Female; Male; Cholesterol, HDL; Sitting Position; Glycated Hemoglobin; Cardiometabolic outcomes; Cohort consortium; Compositional data analysis; Physical activity; Sedentary behaviour; Sleep; Standing; Humans; Female; Adult; Middle Aged; Male; Cholesterol, HDL; Glycated Hemoglobin; Cross-Sectional Studies; Sitting Position; Prospective Studies; Exercise; Triglycerides; Sleep; Cardiovascular Diseases; 32 Biomedical and Clinical Sciences; 3202 Clinical Sciences; Obesity; Cardiovascular; Sleep Research; Prevention; Physical Activity; 3.1 Primary prevention interventions to modify behaviours or promote wellbeing; Stroke; Cardiovascular; Cancer; Metabolic and endocrine; 3 Good Health and Well Being; Humans; Female; Adult; Middle Aged; Male; Cholesterol, HDL; Glycated Hemoglobin; Cross-Sectional Studies; Sitting Position; Prospective Studies; Exercise; Triglycerides; Sleep; Cardiovascular Diseases; 1102 Cardiorespiratory Medicine and Haematology; 1103 Clinical Sciences; Cardiovascular System & Hematology; 3201 Cardiovascular medicine and haematology; 3202 Clinical sciences
Subjects:	R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport and Exercise Sciences
Publisher:	Oxford University Press (OUP)
SWORD Depositor:	A Symplectic
Date Deposited:	12 Mar 2025 10:40
Last Modified:	12 Mar 2025 10:45
DOI or ID number:	10.1093/eurheartj/ehad717
URI:	https://researchonline.ljmu.ac.uk/id/eprint/25858

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