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Abolhasani, S, Ahmadi, Y, Rostami, Y and Fattahi, D (2025) The role of MicroRNAs in mesenchymal stem cell differentiation into vascular smooth muscle cells. Cell Division, 20 (1). pp. 1-9. ISSN 1747-1028
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The role of MicroRNAs in mesenchymal stem cell differentiation into vascular smooth muscle cells.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (886kB) | Preview |
Abstract
MicroRNAs (miRNAs) are small, noncoding RNA molecules that play a vital role in regulating gene expression, especially in the differentiation of mesenchymal stem cells (MSCs) into vascular smooth muscle cells (VSMCs). MSCs hold considerable promise for vascular repair and regenerative medicine, given their ability to differentiate into smooth muscle cells (SMCs) under specific molecular cues. Recent studies have shown that miRNAs, through complex regulatory networks, influence MSC differentiation by targeting essential signaling pathways and modulating the expression of differentiation markers, underscoring the intricate roles of these molecules in cellular development. This review comprehensively examines the functions of various miRNAs in MSC differentiation, focusing on miR-143 and miR-145, which are upregulated by transforming growth factor beta 1 (TGF-β1), a key growth factor in SMC development. These miRNAs enhance differentiation by promoting the expression of SMC markers, including α-smooth muscle actin (α-SMA) and calponin, and by inhibiting factors that preserve MSCs in an undifferentiated state. This review further discusses the roles of miR-503, which supports SMC differentiation through SMAD7 inhibition via the TGF-β pathway, and miR-222-5p, which counteracts differentiation by downregulating ROCK2 and α-SMA. By highlighting these regulatory mechanisms, this review aims to clarify the bidirectional and multifaceted role of miRNAs in VSMC differentiation. This study offers insights into the therapeutic potential of miRNA-mediated MSC differentiation for vascular repair and regeneration, ultimately contributing to improved cardiovascular outcomes.
| Item Type: | Article |
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| Uncontrolled Keywords: | 3101 Biochemistry and Cell Biology; 31 Biological Sciences; Regenerative Medicine; Stem Cell Research; Genetics; Biotechnology; Stem Cell Research - Nonembryonic - Human; Cardiovascular; Stem Cell Research - Nonembryonic - Non-Human; 1.1 Normal biological development and functioning; 2.1 Biological and endogenous factors; 5.2 Cellular and gene therapies; Cardiovascular; 1199 Other Medical and Health Sciences; Developmental Biology; 3101 Biochemistry and cell biology |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy and Biomolecular Sciences |
| Publisher: | BMC Springer Nature |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 13 Mar 2025 15:15 |
| Last Modified: | 13 Mar 2025 15:15 |
| DOI or ID number: | 10.1186/s13008-025-00146-0 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/25891 |
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