Tools
Tools
Liu, W, Li, Y, Shaw, KS, Learn, GH, Plenderleith, LJ, Malenke, JA, Sundararaman, SA, Ramirez, MA, Crystal, PA, Smith, AG, Bibollet-Ruche, F, Ayouba, A, Locatelli, S, Esteban, A, Mouacha, F, Guichet, E, Butel, C, Ahuka-Mundeke, S, Inogwabini, B-I, Ndjango, J-BN , Speede, S, Sanz, CM, Morgan, DB, Gonder, MK, Kranzusch, PJ, Walsh, PD, Georgiev, AV, Muller, MN, Piel, AK, Stewart, FA, Wilson, ML, Pusey, AE, Cui, L, Wang, Z, Farnert, A, Sutherland, CJ, Nolder, D, Hart, JA, Hart, TB, Bertolani, P, Gillis, A, LeBreton, M, Tafon, B, Kiyang, J, Djoko, CF, Schneider, BS, Wolfe, ND, Mpoudi-Ngole, E, Delaporte, E, Carter, R, Culleton, RL, Shaw, GM, Rayner, JC, Peeters, M, Hahn, BH and Sharp, PM (2014) African origin of the malaria parasite Plasmodium vivax. NATURE COMMUNICATIONS, 5 (3346). ISSN 2041-1723
|
Text
African origin of the malaria parasite Plasmodium vivax.pdf - Accepted Version Available under License Creative Commons Attribution. Download (829kB) | Preview |
Abstract
Plasmodium vivax is the leading cause of human malaria in Asia and Latin America but is absent from most of central Africa due to the near fixation of a mutation that inhibits the expression of its receptor, the Duffy antigen, on human erythrocytes. The emergence of this protective allele is not understood because P. vivax is believed to have originated in Asia. Here we show, using a non-invasive approach, that wild chimpanzees and gorillas throughout central Africa are endemically infected with parasites that are closely related to human P. vivax. Sequence analyses reveal that ape parasites lack host specificity and are much more diverse than human parasites, which form a monophyletic lineage within the ape parasite radiation. These findings indicate that human P. vivax is of African origin and likely selected for the Duffy-negative mutation. All extant human P. vivax parasites are derived from a single ancestor that escaped out of Africa.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MD Multidisciplinary |
| Subjects: | Q Science > QL Zoology |
| Divisions: | Natural Sciences & Psychology (closed 31 Aug 19) |
| Publisher: | NATURE PUBLISHING GROUP |
| Related URLs: | |
| Date Deposited: | 18 Jan 2016 13:05 |
| Last Modified: | 04 Sep 2021 13:38 |
| DOI or ID number: | 10.1038/ncomms4346 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/2654 |
 |
View Item |