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Seeger, JPH, Lenting, CJ, Schreuder, THA, Landman, TRJ, Cable, NT, Hopman, MTE and Thijssen, DHJ (2015) Interval exercise, but not endurance exercise, prevents endothelial ischemia-reperfusion injury in healthy subjects. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 308 (4). H351-H357. ISSN 0363-6135
Full text not available from this repository. Please see publisher or open access link below:Abstract
Endothelial ischemia-reperfusion (I/R) injury importantly contributes to the poor prognosis during ischemic (myocardial) events. Preconditioning, i.e., repeated exposure to short periods of ischemia, effectively reduces endothelial I/R injury. In the present study, we examined the hypothesis that exercise has preconditioning effects on endothelial I/R injury. Therefore, we studied whether an acute bout of endurance or interval exercise is able to protect against endothelial I/R injury. In 17 healthy young subjects, we examined changes in brachial artery endothelial function using flow-mediated dilation (FMD) before and after a bout of high-intensity interval exercise, moderate-intensity endurance exercise, or a control intervention. Subsequently, I/R injury was induced by inflation of a blood pressure cuff around the upper arm to 220 mmHg for 20 min and 20 min of reperfusion followed by another FMD measurement. Near-infrared spectrometry was used to examine local tissue oxygenation during exercise. No differences in brachial artery FMD were found at baseline for the three conditions. I/R induced a significant decline in FMD (7.1 ± 2.3 to 4.3 ± 2.3, P < 0.001). When preceded by the interval exercise bout, no change in FMD was present after I/R (7.7 ± 3.1 to 7.2 ± 3.1, P = 0.56), whereas the decrease in FMD after I/R could not be prevented by the endurance exercise bout (7.8 ± 3.1 to 3.8 ± 1.7, P < 0.001). In conclusion, a single bout of lower limb interval exercise, but not moderate-intensity endurance exercise, effectively prevents brachial artery endothelial I/R injury. This indicates the presence of a remote preconditioning effect of exercise, which is selectively present after short-term interval but not continuous exercise in healthy young subjects.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 0606 Physiology, 1116 Medical Physiology |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | AMER PHYSIOLOGICAL SOC |
| Related URLs: | |
| Date Deposited: | 22 Jan 2016 11:33 |
| Last Modified: | 03 Sep 2021 23:24 |
| DOI or ID number: | 10.1152/ajpheart.00647.2014 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/2754 |
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