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Javed, S, Oise, IE, Nahar, L, Ismail, FMD, Mahmood, Z and Sarker, SD (2016) Isolation, identification and antiproliferative activity of triterpenes from the genus Monotheca A. DC. Records of Natural Products, 10 (6). pp. 782-787. ISSN 1307-6167
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Abstract
The Monotheca A. DC. is a monotypic genus of the family Sapotaceae, which is widely distributed in Afghanistan, Djbouti, Northern Somalia, Oman, Pakistan and Southern Ethiopia. North-west Pakistan is the main region where Monotheca buxifolia (Falc.) A. DC., the only species of this genus, locally known as “Gurgura”, grows abundantly. It is an evergreen, fruit-producing medicinal tree. Bioassay-guided fractionation of the aerial parts of M. buxifolia afforded lupeol (1), lupeol acetate (2), betulin (3), oleanolic acid (4) and β-amyrin (5) from the n-hexane and the chloroform fractions. This is the first report on the isolation, and identification of triterpenes (1-5) as the major compounds in the active fractions with antiproliferative property, and also on the antiproliferative activity of M. buxifolia extract and fractions against the human lung cancer cell line NCI-H460 in vitro.
| Item Type: | Article |
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| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | ACG Publications |
| Date Deposited: | 29 Jan 2016 16:15 |
| Last Modified: | 04 Sep 2021 13:32 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/2789 |
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