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Intron analyses reveal multiple calmodulin copies in Littorina

Simpson, RJ, Wilding, CS and Grahame, J (2005) Intron analyses reveal multiple calmodulin copies in Littorina. JOURNAL OF MOLECULAR EVOLUTION, 60 (4). pp. 505-512. ISSN 0022-2844

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Intron three and the flanking exons of the calmodulin gene have been amplified, cloned and sequenced from 18 members of the gastropod genus Littorina. From the 48 sequences, at least five different gene copies have been identified and their functionality characterized using a strategy based upon the potential protein product predicted from flanking exon data. The functionality analyses suggest that four of the genes code for functional copies of calmodulin. All five copies have been identified across a wide range of littorinid species although not ubiquitously. Using this novel approach based on intron sequences, we have identified an unprecedented number of potential calmodulin copies in Littorina, exceeding that reported for any other invertebrate. This suggests a higher number of, and more ancient, gene duplications than previously detected in a single genus.

Item Type: Article
Additional Information: The final publication is available at Springer via http: http://dx.doi.org/10.1007/s00239-004-0232-3
Uncontrolled Keywords: 0601 Biochemistry And Cell Biology, 0603 Evolutionary Biology, 0604 Genetics
Subjects: Q Science > QH Natural history
Q Science > QL Zoology
Divisions: Natural Sciences & Psychology (closed 31 Aug 19)
Publisher: SPRINGER
Related URLs:
Date Deposited: 10 Feb 2016 08:45
Last Modified: 04 Sep 2021 13:26
DOI or ID number: 10.1007/s00239-004-0232-3
URI: https://researchonline.ljmu.ac.uk/id/eprint/2894
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