Delgado-Goñi, T, Ortega Martorell, S, Ciezka, M, Olier, I, Candiota, AP, Julià-Sapé, M, Fernández, F, Pumarola, M, Lisboa, P and Arús, C (2016) MRSI-based molecular imaging of therapy response to temozolomide in preclinical glioblastoma using source analysis. NMR in Biomedicine, 29 (6). pp. 732-743. ISSN 1099-1492

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Abstract

Characterization of Gliobastoma (GB) response to treatment is a key factor for improving patient's survival and prognosis. Magnetic resonance Imaging and Spectroscopic Imaging (MRI/MRSI) provide morphologic and metabolic profiles of GB but usually fail to produce unequivocal biomarkers of response. The purpose of this work is to provide proof-of-concept of the capability of a semi-supervised signal source extraction methodology to produce images with robust recognition of response to temozolomide (TMZ) in a preclinical GB model.

Item Type:	Article
Additional Information:	This is the accepted version of the following article: "MRSI-based molecular imaging of therapy response to temozolomide in preclinical glioblastoma using source analysis", which has been published in final form at http://dx.doi.org/10.1002/nbm.3521
Uncontrolled Keywords:	1103 Clinical Sciences, 0304 Medicinal And Biomolecular Chemistry, 0903 Biomedical Engineering
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions:	Applied Mathematics (merged with Comp Sci 10 Aug 20)
Publisher:	Wiley
Date Deposited:	17 Mar 2016 09:25
Last Modified:	04 Sep 2021 13:10
DOI or ID number:	10.1002/nbm.3521
URI:	https://researchonline.ljmu.ac.uk/id/eprint/3282

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