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Thijssen, DHJ, Maxwell, JP, Green, DJ, Cable, NT and Jones, H (2016) Repeated ischaemic preconditioning: A novel therapeutic intervention and potential underlying mechanisms. Experimental Physiology. ISSN 1469-445X
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Abstract
Ischaemic preconditioning (IPC) refers to the phenomenon that short periods of cyclical tissue ischaemia confer subsequent protection against ischaemia-induced injury. As a consequence, IPC can ameliorate the myocardial damage following infarction and reduce infarct size. The ability of IPC to confer remote protection makes IPC a potentially feasible cardioprotective strategy. In this review, we discuss the concept that repeatedly exposing tissue to IPC may increase the "dose" of protection, and subsequently lead to enhanced protection against ischaemia-induced myocardial injury. This may be relevant for clinical populations, who demonstrate attenuated efficacy of IPC to prevent or attenuate ischaemic injury (and therefore myocardial infarct size). Furthermore, episodic IPC facilitates repeated exposure to local (e.g. shear stress) and systemic (e.g. hormones, cytokines, blood-borne substances) stimuli, which may induce improvement in vascular function and health. Such adaptation may contribute to prevention of cardio- and cerebro-vascular events. The clinical benefits of repeated IPC may, therefore, result from both the prevention of ischaemic events and attenuation of their consequences. We provide an overview of the literature pertaining to the impact of repeated IPC on cardiovascular function, related to both local and or remote adaptation, as well as potential clinical implications. This article is protected by copyright. All rights reserved.
| Item Type: | Article |
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| Additional Information: | This is the peer reviewed version of the following article: Thijssen, D. H.J., Maxwell, J., Green, D. J., Cable, N. T. and Jones, H. (2016), Repeated ischaemic preconditioning: A novel therapeutic intervention and potential underlying mechanisms. Exp Physiol., which has been published in final form at http://dx.doi.org/10.1113/EP085566. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving |
| Uncontrolled Keywords: | 0606 Physiology, 1116 Medical Physiology, 1106 Human Movement And Sports Science |
| Subjects: | Q Science > QP Physiology |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Wiley |
| Related URLs: | |
| Date Deposited: | 18 Mar 2016 12:21 |
| Last Modified: | 04 Sep 2021 13:09 |
| DOI or ID number: | 10.1113/EP085566 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/3290 |
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