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Nanocarriers Targeting Dendritic Cells for Pulmonary Vaccine Delivery

Kunda, NK, Somavarapu, S, Gordon, SB, Hutcheon, GA and Saleem, IY (2013) Nanocarriers Targeting Dendritic Cells for Pulmonary Vaccine Delivery. PHARMACEUTICAL RESEARCH, 30 (2). pp. 325-341. ISSN 0724-8741

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Pulmonary vaccine delivery has gained significant attention as an alternate route for vaccination without the use of needles. Immunization through the pulmonary route induces both mucosal and systemic immunity, and the delivery of antigens in a dry powder state can overcome some challenges such as cold-chain and availability of medical personnel compared to traditional liquid-based vaccines. Antigens formulated as nanoparticles (NPs) reach the respiratory airways of the lungs providing greater chance of uptake by relevant immune cells. In addition, effective targeting of antigens to the most ‘professional’ antigen presenting cells (APCs), the dendritic cells (DCs) yields an enhanced immune response and the use of an adjuvant further augments the generated immune response thus requiring less antigen/dosage to achieve vaccination. This review discusses the pulmonary delivery of vaccines, methods of preparing NPs for antigen delivery and targeting, the importance of targeting DCs and different techniques involved in formulating dry powders suitable for inhalation.

Item Type: Article
Additional Information: The original publication is available at www.springer.com - see Publisher URL
Uncontrolled Keywords: 1115 Pharmacology And Pharmaceutical Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Related URLs:
Date Deposited: 16 Oct 2015 14:15
Last Modified: 01 May 2019 17:31
DOI or Identification number: 10.1007/s11095-012-0891-5
URI: http://researchonline.ljmu.ac.uk/id/eprint/372

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