Nakouti, I, Sihanonth, P, Palaga, T and Hobbs, G (2013) Effect of a siderophore producer on animal cell apoptosis: a possible role as anti-cancer agent. International Journal of Pharma Medicine and Biological Sciences, 2 (3). pp. 1-5. ISSN 2278-5221

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Abstract

Iron plays an essential role in the proliferation of aggressive tumors therefore it represents an ideal target for cancer therapy. Cell free supernatants from a siderophore producing actinobacterium previously isolated from Thailand were tested against six human cancer cell lines including malignant melanoma A 375 (ATCC no.: CRL-1619), colorectal adenocarcinoma SW620 (ATCC
no.: CCL-227), gastric carcinoma Katob III (ATCC no.: HTB-103), liver hepatoblastoma HepG2 (ATCC no.: HB-8065), breast carcinoma BT474 (ATCC no.: HTB-20) and Acute T cell leukemia Jurkat (ATCC no.: CRL-2063). Following treatment of cells with the bacterial culture supernatant the cell viability of A375 cells was dramatically decreased with cell survival of less than 34 % within
48 h. The rest of the cell lines were largely unaffected. Therefore it is suggested that the actinobacterium produced a cytotoxic compound responsible for the cell death by inducing apoptotic activity. We further speculate that this compound was desferioxamine E as the bacterium is known to produce this compound under the culture conditions used.

Item Type:	Article
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy & Biomolecular Sciences
Publisher:	IJPMBS
Date Deposited:	15 Sep 2016 09:06
Last Modified:	04 Sep 2021 12:31
DOI or ID number:	ijpmbs_5159a4b1333fe
URI:	https://researchonline.ljmu.ac.uk/id/eprint/4147

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